Seasonal patterns of myositis-specific and myositis-associated autoantibodies in Italy: Seasonal patterns of myositis autoantibodies.

Autor: Palterer B; Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachussetts, USA. Electronic address: boaz.palterer@childrens.harvard.edu., Mazzoni A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Flow Cytometry Diagnostic Center and Immunotherapy Unit, Careggi University Hospital, Florence, Italy. Electronic address: alessio.mazzoni@unifi.it., Infantino M; Laboratory of Immunology and Allergy, San Giovanni di Dio Hospital, Florence, Italy., Semeraro R; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Manfredi M; Laboratory of Immunology and Allergy, San Giovanni di Dio Hospital, Florence, Italy., Pesce G; Laboratory of Autoimmunology Diagnostics, IRCCS San Martino Policlinic Hospital, Genua, Italy; Department of Internal Medicine and Medical Specialties (DIMI), University of Genua, Genua, Italy., Porcelli B; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Terzuoli L; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Deleonardi G; Laboratory Unico Metropolitano, Maggiore Hospital, Bologna, Italy., Previtali G; Laboratory of Clinical Pathology, Papa Giovanni XXIII Hospital, Bergamo, Italy., Alessio MG; Laboratory of Clinical Pathology, Papa Giovanni XXIII Hospital, Bergamo, Italy., Garrafa E; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Department of Laboratory Diagnostics, ASST Spedali Civili, Brescia, Italy., Ghisellini S; Clinical Pathology Unit, S. Anna University Hospital, Ferrara, Italy., Boni M; Clinical Pathology Unit, S. Anna University Hospital, Ferrara, Italy., Anzivino P; Multi-zone Operating Unit Clinical Pathology Laboratory, Department of Laboratories, APSS of Trento, Trento, Italy., Carbone T; Immunopathology Laboratory, San Carlo Regional Hospital, Potenza, Italy., Sacchi MC; Autoimmunology and Analysis Laboratory Unit, 'SS. Antonio e Biagio e Cesare Arrigo' University Hospital, Alessandria, Italy; Research Laboratory Facility, Research and Innovation Department (DAIRI), 'SS. Antonio e Biagio e Cesare Arrigo' University Hospital, Alessandria, Italy., Sorrentino MC; Department of Laboratory Medicine and Advanced Biotechnologies, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, Italy., Brusca I; Clinical Pathology, Buccheri La Ferla Hospital FBF, Palermo, Italy., Tarricone NR; Operative Unit of Clinical Pathology, 'Bonomo' City Hospital, Andria, ASL BT, Italy., Ghirardello A; Rheumatology Unit, Department of Medicine, University of Padua, Italy., Annunziato F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Flow Cytometry Diagnostic Center and Immunotherapy Unit, Careggi University Hospital, Florence, Italy., Parronchi P; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Immunology and Cell Therapy Unit, Careggi University Hospital, Florence, Italy., Bizzaro N; Laboratory of Clinical Pathology, Azienda Sanitaria Universitaria Integrata, Udine, Italy.
Jazyk: angličtina
Zdroj: Immunology letters [Immunol Lett] 2024 Dec 15; Vol. 272, pp. 106966. Date of Electronic Publication: 2024 Dec 15.
DOI: 10.1016/j.imlet.2024.106966
Abstrakt: Objective: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of systemic autoimmune disorders affecting skeletal muscles but also other organs. There are different forms of IIM, each with peculiar clinical manifestations and prognosis. Accordingly, several autoantibodies have been described in IIM, with different prevalence in the different forms of the disease. The etiopathogenesis of IIM is still unclear, although environmental agents play certainly a role to trigger disease development in genetically predisposed individuals. Supporting this notion, some reports suggest that the incidence of IIM may be different throughout the year. In this work, we tested if the detection of autoantibodies typically observed in IIM has a seasonal pattern.
Methods: We collected serological data from line immunoassays (LIA) performed on 4277 patients with suspected IIM from January 2018 to December 2020 in ten Italian hospitals. Myositis-specific and myositis-associated autoantibodies were evaluated by line-immunoassay.
Results: Our findings demonstrate that absolute numbers of anti-MDA5, anti-PM-Scl75, anti-Mi2b and anti-TIF1ɣ autoantibodies are more frequently detected in autumn-winter than in spring-summer. However, only anti-PM-Scl75 and anti-MDA5 display a similar pattern when analyzing frequencies of positive tests (for anti-PM-Scl75 100 positive tests and 2107 negative tests from September to February; 55 positive tests and 1903 negative tests from March to August, p = 0.003; for anti-MDA5 34 positive tests and 1983 negative tests from September to February; 17 positive tests and 1760 negative tests from March to August, p = 0.051).
Conclusions: These findings suggests that triggering agents promoting the development of these autoantibodies have a specific seasonal pattern.
Competing Interests: Declaration of competing interest The authors declare no competing interest.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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