Assessment of Microcirculation and Microrheological Parameters of Blood in Patients With Type 2 Diabetes Mellitus Using Biophotonics Techniques.

Autor: Umerenkov DA; Department of Physics, Lomonosov Moscow State University, Moscow, Russia., Ermolinskiy PB; Department of Physics, Lomonosov Moscow State University, Moscow, Russia., Lugovtsov AE; Department of Physics, Lomonosov Moscow State University, Moscow, Russia., Fabrichnova AA; Department of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia., Gurfinkel YI; Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia., Dyachuk LI; Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia., Priezzhev AV; Department of Physics, Lomonosov Moscow State University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2024 Dec 16, pp. e202400485. Date of Electronic Publication: 2024 Dec 16.
DOI: 10.1002/jbio.202400485
Abstrakt: In this study, the parameters of blood microcirculation and microrheology were measured using the methods of laser aggregometry and optical tweezers in vitro, as well as the method of digital capillaroscopy in vivo. It was shown that in patients suffering from type 2 diabetes mellitus, an increase in the number of RBC aggregates passing through the narrow capillaries leads to a significant decrease in the velocity of the capillary blood flow, which can be explained by the increased viscosity of the whole blood and decreased deformability of RBCs. Also, for the group of patients, a statistically significant increase in the rate of RBC aggregation and the hydrodynamic strength of aggregates, RBC aggregation and disaggregation forces were observed compared to the control group. We have demonstrated the possibility of using these methods to assess changes in microrheological and microcirculatory parameters of the blood.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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