Anelloviruses and Cancer.
| Autor: | Tang JY; Tufts University, Medford, Massachusetts, USA., Chen TB; MAP program, University of California, San Diego, California, USA., Kouznetsova VL; San Diego Supercomputer Center, University of California, San Diego, California, USA.; BiAna, California, USA.; CureScience Institute, California, USA., Tsigelny IF; San Diego Supercomputer Center, University of California, San Diego, California, USA.; BiAna, California, USA.; Department of Neurosciences, University of California, San Diego, California, USA.; CureScience Institute, California, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of infectious diseases [J Infect Dis] 2024 Dec 16. Date of Electronic Publication: 2024 Dec 16. |
| DOI: | 10.1093/infdis/jiae626 |
| Abstrakt: | Anelloviruses are among the most prevalent viruses within the human virome, detected in over 90% of healthy individuals. Despite their ubiquity, the role of anelloviruses in human health remains elusive. This review examines the potential associations of anelloviruses torque teno virus (TTV), torque teno midi virus (TTMDV), and torque teno mini virus (TTMV) with various cancers, highlighting the mixed conclusions from current epidemiological studies. Anelloviruses may modulate cancer development through abnormal gene fusion, immune response, and toll-like receptor 9 (TLR9) activation. On the other hand, anelloviruses might suppress tumor formation through TTV-derived apoptosis-inducing protein (TAIP) and NF-κB signaling inhibition. The high prevalence of anelloviruses in cancer patients could also be attributed to their immunocompromised status rather than a direct causative role of the viruses. This review underscores the need for more comprehensive studies, including in vitro and in vivo experiments, to clarify the role of anelloviruses in cancer development and progression. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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