Higher intake energy, protein, and polyunsaturated fatty acids at dinner versus breakfast increase the risk of hyperhomocysteinemia among adults in the USA.

Autor: Jia Y; School of Public Health, Qiqihar Medical University, Qiqihar, 161000, China., Ma S; School of Public Health, Qiqihar Medical University, Qiqihar, 161000, China., Chen X; Sanitary Analysis Center, Scientific Research Office, Qiqihar Medical University, Qiqihar, 161000, China., Chen Z; School of Public Health, Qiqihar Medical University, Qiqihar, 161000, China., Yang X; School of Public Health, Qiqihar Medical University, Qiqihar, 161000, China., Li H; School of Public Health, Qiqihar Medical University, Qiqihar, 161000, China., Jiang L; The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, 161000, China., Du L; School of Public Health, Qiqihar Medical University, Qiqihar, 161000, China., Liu L; Modern Educational Technology Center, Qiqihar Medical University, Qiqihar, 161000, China., Ge J; School of Public Health, Qiqihar Medical University, Qiqihar, 161000, China. gejieqiao@126.com.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2024 Dec 16; Vol. 64 (1), pp. 47. Date of Electronic Publication: 2024 Dec 16.
DOI: 10.1007/s00394-024-03567-9
Abstrakt: Purpose: This study analyzed the relation of energy and macronutrient intake at dinner versus breakfast with the risk of hyperhomocysteinemia (Hhcy).
Methods: Up to 12,474 adults, in which 1,387 with Hhcy, completed a questionnaire about energy and macronutrient intake in the National Health and Nutrition Examination. The differences (Δ) in that between dinner and breakfast (Δ = dinner - breakfast) were categorized into quartiles. Logistic regression analyses or restrictive cubic spline regressions were conducted to determine the relation in Δ and the risk of Hhcy, as well as the change in risk when 5% energy at dinner was substituted with those at breakfast through isocaloric substitution models.
Results: After adjusted the confounders, results showed that compared to the research objects in the lowest quartile, those in the highest quartile were more prone to get Hhcy (odds ratio (OR) Δ energy = 1.26, 95% CI = 1.03-1.56; OR Δ protein = 1.25, 95% CI = 1.01-1.55; OR Δ PUFA = 1.22, 95% CI = 1.01-1.49, respectively). Isocalorically replacing 5% energy at dinner with energy at breakfast was related to 5% lower Hhcy risk. Replacing 5% of energy provided by protein at dinner with that by protein or PUFA at breakfast was related to 10% and 11% lower Hhcy risk, respectively. Replacing 5% energy provided by PUFA at dinner with that by protein or PUFA at breakfast were associated with 8% and 6% lower Hhcy risk, respectively.
Conclusion: The optimal intake period for energy, protein, and polyunsaturated fatty acid intake for reducing Hhcy risk in adults was the morning.
Competing Interests: Declarations. Ethical approval: The present research was approved by the ethical committee of Qiqihar Medical University (ref: [2023] 28) and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All participants provided informed consent. Competing interests: The authors declare that they have no conflict of interest.
(© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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