Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution.

Autor:	Lankester F; Paul G. Allen School for Global Health, Washington State University, Pullman, United States.; Global Animal Health Tanzania, Arusha, United Republic of Tanzania., Kibona TJ; Global Animal Health Tanzania, Arusha, United Republic of Tanzania., Allan KJ; School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., de Glanville W; School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Buza JJ; Nelson Mandela African Institution of Science and Technology, Arusha, United Republic of Tanzania., Katzer F; Moredun Research Institute, Pentlands Science Park, Edinburgh, United Kingdom., Halliday JE; School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Mmbaga BT; Kilimanjaro Clinical Research Institute, Moshi, United Republic of Tanzania., Wheelhouse N; School of Applied Sciences, Edinburgh Napier University, Edinburgh, United Kingdom., Innes EA; Moredun Research Institute, Pentlands Science Park, Edinburgh, United Kingdom., Thomas KM; Centre for International Health, University of Otago, Dunedin, New Zealand., Nyasebwa OM; Ministry of Livestock and Fisheries, Dodoma, United Republic of Tanzania., Swai E; Ministry of Livestock and Fisheries, Dodoma, United Republic of Tanzania., Claxton JR; School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Cleaveland S; School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2024 Dec 16; Vol. 13. Date of Electronic Publication: 2024 Dec 16.
DOI:	10.7554/eLife.95296
Abstrakt:	Lack of data on the aetiology of livestock diseases constrains effective interventions to improve livelihoods, food security and public health. Livestock abortion is an important disease syndrome affecting productivity and public health. Several pathogens are associated with livestock abortions but across Africa surveillance data rarely include information from abortions, little is known about aetiology and impacts, and data are not available to inform interventions. This paper describes outcomes from a surveillance platform established in Tanzania spanning pastoral, agropastoral and smallholder systems to investigate causes and impacts of livestock abortion. Abortion events were reported by farmers to livestock field officers (LFO) and on to investigation teams. Events were included if the research team or LFO could attend within 72 hr. If so, samples and questionnaire data were collected to investigate (a) determinants of attribution; (b) patterns of events, including species and breed, previous abortion history, and seasonality; (c) determinants of reporting, investigation and attribution; (d) cases involving zoonotic pathogens. Between 2017-2019, 215 events in cattle (n=71), sheep (n=44), and goats (n=100) were investigated. Attribution, achieved for 19.5% of cases, was significantly affected by delays in obtaining samples. Histopathology proved less useful than PCR due to rapid deterioration of samples. Vaginal swabs provided practical and sensitive material for pathogen detection. Livestock abortion surveillance, even at a small scale, can generate valuable information on causes of disease outbreaks, reproductive losses and can identify pathogens not easily captured through other forms of livestock disease surveillance. This study demonstrated the feasibility of establishing a surveillance system, achieved through engagement of community-based field officers, establishment of practical sample collection and application of molecular diagnostic platforms. Competing Interests: FL, TK, KA, Wd, JB, FK, JH, BM, NW, EI, KT, ON, ES, JC, SC No competing interests declared (© 2024, Lankester et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu