Deeply Implantable, Shape-Morphing, 3D MicroLEDs for Pancreatic Cancer Therapy.

Autor: Lee JH; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA., Lee CG; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Kim MS; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Kim S; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Song M; Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Zhang H; Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, 60208, USA., Yang E; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Kwon YH; O2MEDi Incorporation, Ulsan, 44919, Republic of Korea., Jung YH; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Hyeon DY; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Choi YJ; In Vivo Research Center, UNIST Central Research Facilities, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea., Oh S; Division of Electrical Engineering, Hanyang University ERICA, Ansan, 15588, Republic of Korea., Joe DJ; Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS), Daejeon, 34113, Republic of Korea., Kim TS; Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Jeon S; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Huang Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA.; Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, 60208, USA.; Departments of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA., Kwon TH; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.; O2MEDi Incorporation, Ulsan, 44919, Republic of Korea., Lee KJ; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Dec 16, pp. e2411494. Date of Electronic Publication: 2024 Dec 16.
DOI: 10.1002/adma.202411494
Abstrakt: Controlled photooxidation-mediated disruption of collagens in the tumor microenvironment can reduce desmoplasia and enhance immune responsiveness. However, achieving effective light delivery to solid tumors, particularly those with dynamic volumetric changes like pancreatic ductal adenocarcinoma (PDAC), remains challenging and limits the repeated and sustained photoactivation of drugs. Here, 3D, shape-morphing, implantable photonic devices (IPDs) are introduced that enable tumor-specific and continuous light irradiation for effective metronomic photodynamic therapy (mPDT). This IPD adheres seamlessly to the surface of orthotopic PDAC tumors, mitigating issues related to mechanical mismatch, delamination, and internal lesions. In freely moving mouse models, mPDT using the IPD with close adhesion significantly reduces desmoplastic tumor volume without causing cytotoxic effects in healthy tissues. These promising in vivo results underscore the potential of an adaptable and unidirectional IPD design in precisely targeting cancerous organs, suggesting a meaningful advance in light-based therapeutic technologies.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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