Imaging of prostate micro-architecture using three-dimensional wide-field optical coherence tomography.

Autor:	Skrok MK; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, 5 Grudziądzka St., 87-100 Toruń, Poland., Tamborski S; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, 5 Grudziądzka St., 87-100 Toruń, Poland., Hepburn MS; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, 5 Grudziądzka St., 87-100 Toruń, Poland.; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, 35 Stirling Highway, Perth 6009, Western Australia, Australia.; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Western Australia 6009, Australia., Fang Q; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, 35 Stirling Highway, Perth 6009, Western Australia, Australia.; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Western Australia 6009, Australia., Maniewski M; Department of Obstetrics, Gynaecology and Oncology, Chair of Pathomorphology and Clinical Placentology, Collegium Medicum Jan Biziel University Hospital, 75 Ujejskiego St., Bydgoszcz 85-168, Poland.; Department of Tumor Pathology and Pathomorphology, Oncology Centre, Prof Franciszek Łukaszczyk Memorial Hospital, 2 Romanowskiej St., Bydgoszcz 85-796, Poland., Zdrenka M; Department of Tumor Pathology and Pathomorphology, Oncology Centre, Prof Franciszek Łukaszczyk Memorial Hospital, 2 Romanowskiej St., Bydgoszcz 85-796, Poland., Szkulmowski M; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, 5 Grudziądzka St., 87-100 Toruń, Poland., Kowalewski A; Department of Tumor Pathology and Pathomorphology, Oncology Centre, Prof Franciszek Łukaszczyk Memorial Hospital, 2 Romanowskiej St., Bydgoszcz 85-796, Poland.; Center of Medical Sciences, University of Science and Technology, 7 Kaliskiego St., Bydgoszcz 85-796, Poland., Szylberg Ł; Department of Obstetrics, Gynaecology and Oncology, Chair of Pathomorphology and Clinical Placentology, Collegium Medicum Jan Biziel University Hospital, 75 Ujejskiego St., Bydgoszcz 85-168, Poland.; Department of Tumor Pathology and Pathomorphology, Oncology Centre, Prof Franciszek Łukaszczyk Memorial Hospital, 2 Romanowskiej St., Bydgoszcz 85-796, Poland., Kennedy BF; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, 5 Grudziądzka St., 87-100 Toruń, Poland.; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, 35 Stirling Highway, Perth 6009, Western Australia, Australia.; BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Western Australia 6009, Australia.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2024 Nov 14; Vol. 15 (12), pp. 6816-6833. Date of Electronic Publication: 2024 Nov 14 (Print Publication: 2024).
DOI:	10.1364/BOE.537783
Abstrakt:	Prostate cancer is a global health issue that requires new diagnostic methods to provide accurate and precise visualization of prostate tissue on the micro-scale. Such methods have the potential to improve nerve-sparing surgery and to provide image guidance during prostate biopsy. In this feasibility study, we assess the potential of en face three-dimensional wide-field optical coherence tomography (OCT), covering a volumetric imaging field-of-view up to 46 × 46 × 1 mm 3 , to visualize micro-architecture in 18 freshly excised human prostate specimens. In each case, validation of contrast in OCT images is provided by co-registered wide-field histology images. Using this co-registration, we demonstrate that OCT can distinguish between healthy and cancerous glands at different stages, as well as visualize micro-architecture in the prostate, such as epineurium and perineurium in nerves and the tunica intima and tunica media in blood vessels. Competing Interests: BFK: OncoRes Medical (F, I). The other authors declare that there are no conflicts of interest related to this article. (© 2024 The Author(s).)
Databáze:	MEDLINE
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