Use of a predictor cue during a speech sound discrimination task in a Cntnap2 knockout rat model of autism.

Autor:	Centanni TM; Department of Psychology, Texas Christian University, Fort Worth, TX 76129.; Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, FL 32610., Gunderson LPK; Department of Psychology, Texas Christian University, Fort Worth, TX 76129., Parra M; Department of Psychology, Texas Christian University, Fort Worth, TX 76129.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.
DOI:	10.1101/2024.12.04.626861
Abstrakt:	Autism is a common neurodevelopmental disorder that despite its complex etiology, is marked by deficits in prediction that manifest in a variety of domains including social interactions, communication, and movement. The tendency of individuals with autism to focus on predictable schedules and interests that contain patterns and rules highlights the likely involvement of the cerebellum in this disorder. One candidate-autism gene is contact in associated protein 2 ( CNTNAP2 ), and variants in this gene are associated with sensory deficits and anatomical differences. It is unknown, however, whether this gene directly impacts the brain's ability to make and evaluate predictions about future events. The current study was designed to answer this question by training a genetic knockout rat on a rapid speech sound discrimination task. Rats with Cntnap2 knockout (KO) and their littermate wildtype controls (WT) were trained on a validated rapid speech sound discrimination task that contained unpredictable and predictable targets. We found that although both genotype groups learned the task in both unpredictable and predictable conditions, the KO rats responded more often to distractors during training as well as to the target sound during the predictable testing conditions compared to the WT group. There were only minor effects of sex on performance and only in the unpredictable condition. The current results provide preliminary evidence that removal of this candidate-autism gene may interfere with the learning of unpredictable scenarios and enhance reliance on predictability. Future research is needed to probe the neural anatomy and function that drives this effect. Competing Interests: This work was partially funded by 1R15HD103479-01A1 to TMC. The authors have no other competing financial interests.
Databáze:	MEDLINE
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