Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.

Autor: Leung YY; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Lee WP; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Kuzma AB; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Nicaretta H; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Valladares O; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Gangadharan P; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Qu L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Zhao Y; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Ren Y; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Cheng PL; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Kuksa PP; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Wang H; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., White H; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Katanic Z; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Bass L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Saravanan N; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Greenfest-Allen E; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Kirsch M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Cantwell L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Iqbal T; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wheeler NR; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Farrell JJ; Department of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Zhu C; Department of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Turner SL; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Gunasekaran TI; Columbia University Irving Medical Center, New York, NY, USA.; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Mena PR; Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Jin J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Carter L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Zhang X; Department of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Vardarajan BN; Columbia University Irving Medical Center, New York, NY, USA.; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Toga A; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California., Cuccaro M; Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Hohman TJ; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Bush WS; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Naj AC; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Martin E; Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Dalgard C; Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Kunkle BW; Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Farrer LA; Department of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Mayeux RP; Columbia University Irving Medical Center, New York, NY, USA.; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Haines JL; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Pericak-Vance MA; Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Schellenberg GD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania., Wang LS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.
DOI: 10.1101/2024.12.03.24317000
Abstrakt: The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, detailed phenotypes from 15,927 participants across 10 domains are also provided. A linkage disequilibrium panel was created using unrelated AD cases and controls. Researchers can access and analyze the genetic data via NIAGADS Data Sharing Service, the VariXam tool, or NIAGADS GenomicsDB.
Databáze: MEDLINE