Abnormalities in gut virome signatures linked with cognitive impairment in older adults.

Autor: James AS; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Adil NA; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Goltz D; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Tangudu D; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Chaudhari DS; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Shukla R; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Kumar V; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Kumar A; Research Methodology and Biostatistics, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Masternak MM; School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA., Holland P; Department of Neuroscience, FAU Schmidt College of Medicine/i-Health FAU, Boca Raton, FL, USA., Labyak C; Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA., Golden A; School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA., Dangiolo M; School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA., Arikawa AY; Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA., Kociolek J; Department of Neuroscience, FAU Schmidt College of Medicine/i-Health FAU, Boca Raton, FL, USA.; Clinical Research Unit, Division of Research, Florida Atlantic University, Boca Raton, FL, USA., Fraser A; School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA., Williams C; School of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA., Agronin M; Behavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA., Aymat M; Behavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA., Jain S; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Yadav H; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Jazyk: angličtina
Zdroj: Gut microbes [Gut Microbes] 2024 Jan-Dec; Vol. 16 (1), pp. 2431648. Date of Electronic Publication: 2024 Dec 16.
DOI: 10.1080/19490976.2024.2431648
Abstrakt: Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets ( n  = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs. 70s vs. 80+ years of age) in older adults. We observed that the predominant virome signature was enriched with bacteriophages, which change considerably with aging continuum. Analyses of interactions between phages and the host bacteriome suggest that lytic or temperate relationships change distinctly across the aging continuum, as well as cognitive impairment. Interestingly, the phage-bacteriome-metabolome interactions develop unique patterns that are distinctly linked to aging and cognitive dysfunction in older adults. The phage-bacteriome interactions affect bacterial metabolic pathways, potentially impacting older adults' health, including the risk of cognitive decline and dementia. Further comprehension of these studies could provide opportunities to target the microbiome by developing phage therapies to improve aging and brain health in older adults.
Databáze: MEDLINE