Distinct Tissue-Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells.

Autor: Rødahl IE; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Ivarsson MA; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Loh L; Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, USA., Mold JE; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Westgren M; Center for Fetal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden., Friberg D; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Mjösberg J; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.; Clinical Lung- and Allergy Research Unit, Medical Unit for Lung and Allergy Diseases, Karolinska University Hospital Huddinge, Stockholm, Sweden., Björkström NK; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Marquardt N; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Nixon DF; Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, USA., Michaëlsson J; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2024 Dec 15, pp. e202451150. Date of Electronic Publication: 2024 Dec 15.
DOI: 10.1002/eji.202451150
Abstrakt: The human fetal immune system starts to develop in the first trimester and likely plays a crucial role in fetal development and maternal-fetal tolerance. Innate lymphoid cells (ILCs) are the earliest lymphoid cells to arise in the human fetus. ILCs consist of natural killer (NK) cells, ILC1s, ILC2s, and ILC3s that all share a common lymphoid origin. Here, we studied fetal ILC subsets, mainly NK cells and ILC3s and their potential progenitors, across human fetal tissues. Our results show that fetal ILC subsets have distinct distribution, developmental kinetics, and gene expression profiles across human fetal tissues. Furthermore, we identify CD34 + RORγt + Eomes - and CD34 + RORγt + Eomes + cells in the fetal intestine, indicating that tissue-specific ILC progenitors exist already during fetal development.
(© 2024 The Author(s). European Journal of Immunology published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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