Topical high concentration oxygen with hyaluronic acid: A safe and effective treatment for vaginal atrophy and sexual function improvement.

Autor: Lami A; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Manta AC; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Amati V; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Alvisi S; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Baldassarre M; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Carli A; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Lucchetta G; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Seracchioli R; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Meriggiola MC; Gynecology and Physiopathology of Human Reproduction, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy.
Jazyk: angličtina
Zdroj: Post reproductive health [Post Reprod Health] 2024 Dec 15, pp. 20533691241307804. Date of Electronic Publication: 2024 Dec 15.
DOI: 10.1177/20533691241307804
Abstrakt: Background: Genitourinary syndrome of menopause (GSM) is a condition affecting many postmenopausal women. Among the available treatments, the vaginal natural oxygenation device (VNOD) is a new promising option.
Aim: To evaluate the safety and the effectiveness of vaginal high concentration (HC) oxygen (O 2 ) and hyaluronic acid (HA) in postmenopausal women with vaginal atrophy (VA).
Methods: Study 1: Ten subjects received HA and O 2 at a concentration of 21% (sham group) and ten at 95% (treatment group). All subjects completed five sessions of VNOD. Evaluations and questionnaires were completed at baseline, before each session and at one-month follow-up: Visual Analogue Scale, Vaginal Health Index (VHI), Vaginal Maturation Value (VMV), Menopause Quality Of Life (MeNQoL), Female sexual function index (FSFI) and Female sexual distress scale (FSDS). Study 2: 52 postmenopausal women with VA completed the same protocol of study 1 with HC O 2 and HA.
Results: Treatment was well-tolerated. In study 1, in the treatment group we recorded significant improvements in VHI score ( p -value 0.001), VMV ( p -value 0.005) and in the psychosocial, physical and sexual domains of the MeNQoL compared to sham group. In study 2, all women experienced a significant improvement in VHI ( p -value <0.001), FSFI total score ( p -value 0.007), desire ( p -value 0.004), lubrication ( p -value 0.006), satisfaction ( p -value 0.042), pain ( p -value 0.001) domains, FSDS score ( p -value 0.003) and MeNQoL sexual domain ( p -value <0.001).
Conclusion: The preliminary results of this study suggest that VNOD is a safe and effective treatment for VA in postmenopausal women, and improves sexual function.
Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: MCM declares fees for lectures, membership of advisory boards, and consultancy from Gedeon Richter, MSD, Shionogi, Italfarmaco and Theramex. MB have had financial relationships (lecturer) with Shionogi Ltd. AL declares fees for lectures for Funziona SRL, Exeltis and Theramex.
Databáze: MEDLINE
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