Recent advances in modifications, biotechnology, and biomedical applications of chitosan-based materials: A review.

Autor: Yu Y; College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen 361021, Fujian, China., Su Z; College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen 361021, Fujian, China., Peng Y; College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen 361021, Fujian, China., Zhong Y; College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen 361021, Fujian, China., Wang L; College of Chemistry and Environment, Ankang University, Qinba Chinese Medicine Resources R&D Center, Ankang 725000, Shaanxi, China. Electronic address: wanglin@hqu.edu.cn., Xin M; College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen 361021, Fujian, China. Electronic address: mhxin@hqu.edu.cn., Li M; College of Material Science and Engineering, Huaqiao University, Engineering Research Center of Environment-Friendly Functional Materials, Ministry of Education, Xiamen 361021, Fujian, China. Electronic address: mcli@hqu.edu.cn.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Dec 13; Vol. 289, pp. 138772. Date of Electronic Publication: 2024 Dec 13.
DOI: 10.1016/j.ijbiomac.2024.138772
Abstrakt: Chitosan, a natural polysaccharide with recognized biocompatibility, non-toxicity, and cost-effectiveness, is primarily sourced from crustacean exoskeletons. Its inherent limitations such as poor water solubility, low thermal stability, and inadequate mechanical strength have hindered its widespread application. However, through modifications, chitosan can exhibit enhanced properties such as water solubility, antibacterial and antioxidant activities, adsorption capacity, and film-forming ability, opening up avenues for diverse applications. Despite these advancements, realizing the full potential of modified chitosan remains a challenge across various fields. The purpose of this review article is to conduct a comprehensive evaluation of the chemical modification techniques of chitosan and their applications in biotechnology and biomedical fields. It aims to overcome the inherent limitations of chitosan, such as low water solubility, poor thermal stability, and inadequate mechanical strength, thereby expanding its application potential across various domains. This review is structured into two main sections. The first part delves into the latest chemical modification techniques for chitosan derivatives, encompassing quaternization, Schiff base formation, acylation, carboxylation, and alkylation reactions. The second part provides an overview of the applications of chitosan and its derivatives in biotechnology and biomedicine, spanning areas such as wastewater treatment, the textile and food industries, agriculture, antibacterial and antiviral activities, drug delivery systems, wound dressings, dental materials, and tissue engineering. Additionally, the review discusses the challenges associated with these modifications and offers insights into potential future developments in chitosan-based materials. This review is anticipated to offer theoretical insights and practical guidance to scientists engaged in biotechnology and biomedical research.
Competing Interests: Declaration of competing interest We declare that we have no financial or personal relationships with any individuals or organizations that could inappropriately influence our work.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: