Large-scale georeferenced neuroimaging and psychometry data link the urban environmental exposome with brain health.

Autor: Ruas MV; Geospatial Molecular Epidemiology Group (GEOME), Laboratory for Biological Geochemistry (LGB), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Vajana E; Institute of Biosciences and Bioresources (IBBR-FI), National Research Council (CNR), Sesto Fiorentino, Italy., Kherif F; LREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Lutti A; LREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Preisig M; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Strippoli MP; Psychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., von Gunten A; Psychiatry of Old Age, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Joost S; Geospatial Molecular Epidemiology Group (GEOME), Laboratory for Biological Geochemistry (LGB), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Unit of Population Epidemiology (UEP), Division of Primary Care Medicine (SMPR), Geneva University Hospitals (HUG), Geneva, Switzerland; La Source School of Nursing, University of Applied Sciences and Arts Western Switzerland (HES-SO), Lausanne, Switzerland; Group of Geographic Information Research and Analysis in Population Health (GIRAPH), Geneva, Switzerland. Electronic address: stephane.joost@epfl.ch., Draganski B; LREN, Centre for Research in Neurosciences, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Neurology Department and Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland; Neurology Department, Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Electronic address: bogdan.draganski@insel.ch.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Dec 13; Vol. 267, pp. 120632. Date of Electronic Publication: 2024 Dec 13.
DOI: 10.1016/j.envres.2024.120632
Abstrakt: In face of cumulating evidence about the impact of human-induced environmental changes on mental health and behavior, our understanding of the main effects and interactions between environmental factors - i.e., the exposome and the brain - is still limited. We seek to fill this knowledge gap by leveraging georeferenced large-scale brain imaging and psychometry data from the adult community-dwelling population (n = 2672; mean age 63 ± 10 years). For monitoring brain anatomy, we extract morphometry features from a nested subset of the cohort (n = 944) with magnetic resonance imaging. Using an iterative analytical strategy testing the moderator role of geospatially encoded exposome factors on the association between brain anatomy and psychometry, we demonstrate that individuals' anxiety state and psychosocial functioning are among the mental health characteristics showing associations with the urban exposome. The clusters of higher anxiety state and lower current psychosocial functioning coincide spatially with a lower vegetation density and higher air pollution. The univariate multiscale geographically weighted regression identifies the spatial scale of associations between individuals' levels of anxiety state, psychosocial functioning, and overall cognition with vegetation density, air pollution and structures of the limbic network. Moreover, the multiscale geographically weighted regression interaction model reveals spatially confined exposome features with moderating effect on the brain-psychometry/cognitive performance relationships. Our original findings testing the role of exposome factors on brain and behavior at the individual level, underscore the role of environmental and spatial context in moderating brain-behavior dynamics across the adult lifespan.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Bogdan Draganski and Stephane Joost reports financial support was provided by Swiss National Science Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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