The Oral-Gut-Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke.

Autor: Zhong Y; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Kang X; Department of Anesthesiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Bai X; Department of Oral and Maxillofacial Surgery, Stomatology Hospital, Zhejiang University School of Medicine, Zhejiang, China., Pu B; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China., Smerin D; Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Zhao L; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China., Xiong X; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Jazyk: angličtina
Zdroj: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Dec; Vol. 30 (12), pp. e70152.
DOI: 10.1111/cns.70152
Abstrakt: Periodontitis, a non-communicable chronic inflammation disease resulting from dysbiosis of the oral microbiota, has been demonstrated to have a positive association with the risk of ischemic stroke (IS). The major periodontal pathogens contribute to the progression of stroke-related risk factors such as obesity, diabetes, atherosclerosis, and hypertension. Transcriptional changes in periodontitis pathogens have been detected in oral samples from stroke patients, suggesting a new conceptual framework involving microorganisms. The bidirectional regulation between the gut and the central nervous system (CNS) is mediated by interactions between intestinal microflora and brain cells. The connection between the oral cavity and gut through microbiota indicates that the oral microbial community may play a role in mediating complex communication between the oral cavity and the CNS; however, underlying mechanisms have yet to be fully understood. In this review, we present an overview of key concepts and potential mechanisms of interaction between the oral-gut-brain axis based on previous research, focusing on how the oral microbiome (especially the periodontal pathogens) impacts IS and its risk factors, as well as the mediating role of immune system homeostasis, and providing potential preventive and therapeutic approaches.
(© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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