Differences in Emotional Awareness Moderate Cytokine-Symptom Associations Among Breast Cancer Survivors.

Autor: Harel K; The School of Creative Arts Therapies, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. Electronic address: kharel01@campus.haifa.ac.il., Czamanski-Cohen J; The School of Creative Arts Therapies, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel; The Emili Sagol Creative Arts Therapies Research Center, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel., Cohen M; The School of Social Work, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel., Lane RD; Department of Psychiatry, University of Arizona, Tucson, AZ., Dines M; The School of Creative Arts Therapies, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel; Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Caspi O; The Integrative Medicine and Survivorship Clinics, Davidoff Cancer Center, Rabin Medical Center, Petach Tikvah, Israel., Weihs KL; Department of Psychiatry, University of Arizona, Tucson, AZ; Arizona Cancer Center, University of Arizona, Tucson, AZ.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2024 Dec 12; Vol. 124, pp. 387-396. Date of Electronic Publication: 2024 Dec 12.
DOI: 10.1016/j.bbi.2024.12.005
Abstrakt: Cancer survivors have elevated levels of proinflammatory cytokines, which could be associated with cancer-related symptoms. Given that proinflammatory cytokines heighten negative affect by directly affecting the brain, we explored these direct associations and whether differences in levels of emotional awareness moderate the associations between proinflammatory cytokines and cancer-related symptoms. This cross-sectional, secondary analysis of baseline data was collected from 162 female breast cancer survivors (aged 36-70 years), who were enrolled 6 ± 4 months after completing cancer treatment. We tested cytokines in serum (IL-1β, IL-6, IL-8, TNF-α, IL-4, IL-10, and TGF-β) and assessed depression, cancer-related fatigue, pain intensity, and pain interference. Emotional awareness was assessed using a performance measure, the Levels of Emotional Awareness Scale. In participants with high but not average or low levels of emotional awareness, positive associations were found for IL-1β, IL-6, and TNF-α with depression and between IL-6 and TNF-α with pain intensity. In addition, IL-6 had a positive association with pain intensity at average levels of emotional awareness. These results suggest that women with high or in some cases average, but not low, emotional awareness reported depression and pain as being positively associated with their cytokine levels. By using emotional awareness as a cognitive resource to promote emotion regulation and distress transformation, interventions may be able to counteract heightened sensitivity to the mood-altering effects of cytokines.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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