Ability of brazilian Bothrops-Lachesis-Crotalus antivenom in neutralizing some biological activities of Crotalus durissus ruruima rattlesnake venom.

Autor: Muniz EG; Department of Epidemiology and Public Health, Dr Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, 69040-000, Brazil. Electronic address: emiromuniz28@hotmail.com., Sano-Martins IS; Pathophysiology Laboratory, Butantan Institute, São Paulo, 05503-900, Brazil., Saraiva MDGG; Department of Epidemiology and Public Health, Dr Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, 69040-000, Brazil., Magno ES; Department of Epidemiology and Public Health, Dr Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, 69040-000, Brazil., Oliveira SS; Teaching and Research Center, Francisca Mendes Heart Hospital Foundation, Manaus, 69097-720, Brazil; Research management, Hospital Foundation of Hematology and Hemotherapy of Amazonas, 69050-001, Brazil. Electronic address: oliveira.samella@gmail.com.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Dec 17; Vol. 254, pp. 108211. Date of Electronic Publication: 2024 Dec 17.
DOI: 10.1016/j.toxicon.2024.108211
Abstrakt: We evaluated the efficacy of freeze-dried Bothrops-Lachesis-Crotalus antivenom and liquid Crotalus antivenoms to neutralize Crotalus durissus ruruima (Cdr) venom (Roraima, Brazil) comparing with C. d. terrificus (Cdt) venom. Lethal and phospholipase A 2 activities were similar between both spp. Crotamine was negative and individual Cdr venoms induced hemorrhage in mice. It was lower coagulant than Cdt venom. Only Bothrops-Lachesis-Crotalus antivenom neutralized all biological activities evaluated, suggesting that it could be used in snakebites in this region.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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