Artificial digestion represents the worst-case scenario for studying nanoplastic fate in gastrointestinal tract.

Autor: Lee G; School of Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan., Jhang YJ; Master Program in Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan., Jhang YT; Master Program in Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan., Chang YC; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan; School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan., Chang HW; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan; School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan., Chuang CY; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan., Chuang YK; School of Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; Master Program in Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan., Lin CW; Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106319, Taiwan., Hsiao IL; School of Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; Master Program in Food Safety, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. Electronic address: ilunhsiao@tmu.edu.tw.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2024 Dec 09; Vol. 485, pp. 136809. Date of Electronic Publication: 2024 Dec 09.
DOI: 10.1016/j.jhazmat.2024.136809
Abstrakt: Humans may inevitably be exposed to nanoplastics (NPls) through ingestion. The size of NPls significantly influences their absorption efficiency, so understanding behaviors of NPls during digestion is vital for risk assessment. In this study, fluorescent polystyrene (PS) and melamine-formaldehyde resin (MF) NPls were characterized by different techniques after the in vitro digestion process both with and without a standard food model, or with and without pH adjustment in the absence of the proteins. Results derived from the in vitro method were compared to those using human and porcine digestive fluids. In summary, different types/charges of NPls caused distinct agglomeration states during the digestion procedure, and the pH and protein corona affected the agglomeration state of smaller PS particles more obviously than they did the other tested particles. The presence of a food matrix did not significantly change the particle size, while the protein corona composition was largely altered. Compared to real digestive fluids, size trends observed for NPls were consistent with those in artificial ones, while they were mostly underestimated, which for the first time, proves that the in vitro digestion can be regarded as a conservative model for predicting aggregation of NPls in gastrointestinal tract.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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