How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?

Autor: Higi L; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. lukas.higi@unibas.ch.; PEDeus Ltd, Zurich, Switzerland. lukas.higi@unibas.ch., Carydias E; Pharmacoepidemiology Group, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland., Burden AM; Pharmacoepidemiology Group, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland., Vonbach P; PEDeus Ltd, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Paediatric drugs [Paediatr Drugs] 2024 Dec 14. Date of Electronic Publication: 2024 Dec 14.
DOI: 10.1007/s40272-024-00674-2
Abstrakt: Background: Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited amount of label information, several paediatric drug formularies have been developed. This study compares anti-infective drug dosing recommendations across three European formularies.
Methods: Recommendations from three paediatric formularies (German Pediatric Formulary [GPF], SwissPedDose [SPD] and the British National Formulary for Children [BNF]) were collected. Using population growth curves, we simulated one child for each month from 1 month up to 18 years of age. The recommendations from each formulary were used to calculate doses for each simulated child. Equivalence and difference in calculated doses were analysed.
Results: In total, dosing recommendations for 34 anti-infective substances were collected with 74 corresponding indications, which resulted in 47,154 calculated doses. The mean (± standard deviation) proportion of equivalent doses (difference ≤10%) across all three formularies was 40% (±16), while for pairwise comparisons it was 53% (±19) for GPF versus BNF, 67% (±14) for GPF versus SPD and 52% (±19) for SPD versus BNF. The median [25th quantile, 75th quantile] differences in daily doses across all three formularies were 0%, [0, 26] while for pairwise comparisons it was 4% [0, 32] for GPF versus BNF, 0% [0, 17] for GPF versus SPD and 7% [0, 33] for SPD versus BNF.
Conclusions: The majority of recommended anti-infective drug doses were consistent, with the highest equivalence found between GPF and SPD. Maintaining formularies is resource intensive; therefore, a common standard in Europe could prove beneficial when moving towards digitalisation of the healthcare systems.
Competing Interests: Declarations. Funding: Open access funding provided by University of Basel. Conflict of Interests: Lukas Higi as a PhD student is funded by PEDeus Ltd., Priska Vonbach is the CEO of PEDeus Ltd. The PEDeus Ltd. is a 100% subsidiary company of the University Children’s Hospital of Zurich. None of the authors has any ownership in either institution. The authors have no additional conflicts of interest to declare that are relevant to the content of this article. Ethics Approval: No ethics approval was necessary for this study as it did not involve human or animal subjects. Consent to Participate: Not applicable. Consent for Publication: Not applicable. Availability of Data and Material: Data from two of the formularies (GPF and SPD) are publicly available via the corresponding website. Data from the BNF are not publicly available outside of the UK. Data from the Swiss growth charts are available from the Swiss Pediatrics Society. Code Availability: Not applicable. Authors’ Contributions: Conceptualisation: LH, EC, AMB, PV. Analysis: EC, LH. Writing (original draft preparation): EC, LH. Writing (review and editing): AMB, EC, LH, PV. Project administration: LH, PV. Supervision: AMB, PV. Funding acquisition: PV.
(© 2024. The Author(s).)
Databáze: MEDLINE
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