Perspectives on biomarkers of reproductive aging for fertility and beyond.

Autor: Wang S; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. wangsi@xwh.ccmu.edu.cn.; Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China. wangsi@xwh.ccmu.edu.cn.; Aging Biomarker Consortium, Beijing, China. wangsi@xwh.ccmu.edu.cn., Ren J; Aging Biomarker Consortium, Beijing, China.; Key Laboratory of RNA Science and Engineering, China National Center for Bioinformation, Beijing, China.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Jing Y; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.; Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China., Qu J; Aging Biomarker Consortium, Beijing, China. qujing@ioz.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.; Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.; Institute for Stem Cell and Regeneration, CAS, Beijing, China. qujing@ioz.ac.cn.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. qujing@ioz.ac.cn., Liu GH; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. ghliu@ioz.ac.cn.; Aging Biomarker Consortium, Beijing, China. ghliu@ioz.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.; Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.; Institute for Stem Cell and Regeneration, CAS, Beijing, China. ghliu@ioz.ac.cn.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ghliu@ioz.ac.cn.
Jazyk: angličtina
Zdroj: Nature aging [Nat Aging] 2024 Dec; Vol. 4 (12), pp. 1697-1710. Date of Electronic Publication: 2024 Dec 13.
DOI: 10.1038/s43587-024-00770-5
Abstrakt: Reproductive aging, spanning an age-related functional decline in the female and male reproductive systems, compromises fertility and leads to a range of health complications. In this Perspective, we first introduce a comprehensive framework for biomarkers applicable in clinical settings and discuss the existing repertoire of biomarkers used in practice. These encompass functional, imaging-based and biofluid-based biomarkers, all of which reflect the physiological characteristics of reproductive aging and help to determine the reproductive biological age. Next, we delve into the molecular alterations associated with aging in the reproductive system, highlighting the gap between these changes and their potential as biomarkers. Finally, to enhance the precision and practicality of assessing reproductive aging, we suggest adopting cutting-edge technologies for identifying new biomarkers and conducting thorough validations in population studies before clinical applications. These advancements will foster improved comprehension, prognosis and treatment of subfertility, thereby increasing chances of preserving reproductive health and resilience in populations of advanced age.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. Springer Nature America, Inc.)
Databáze: MEDLINE
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