Hallmarks of female reproductive aging in physiologic aging mice.

Autor: Balough JL; Center for Reproductive Longevity and Equality, Buck Institute for Research on Aging, Novato, CA, USA., Dipali SS; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Velez K; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Kumar TR; Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Duncan FE; Center for Reproductive Longevity and Equality, Buck Institute for Research on Aging, Novato, CA, USA. f-duncan@northwestern.edu.; Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. f-duncan@northwestern.edu.
Jazyk: angličtina
Zdroj: Nature aging [Nat Aging] 2024 Dec; Vol. 4 (12), pp. 1711-1730. Date of Electronic Publication: 2024 Dec 13.
DOI: 10.1038/s43587-024-00769-y
Abstrakt: The female reproductive axis is one of the first organ systems to age, which has consequences for fertility and overall health. Here, we provide a comprehensive overview of the biological process of female reproductive aging across reproductive organs, tissues and cells based on research with widely used physiologic aging mouse models, and describe the mechanisms that underpin these phenotypes. Overall, aging is associated with dysregulation of the hypothalamic-pituitary-ovarian axis, perturbations of the ovarian stroma, reduced egg quantity and quality, and altered uterine morphology and function that contributes to reduced capacity for fertilization and impaired embryo development. Ultimately, these age-related phenotypes contribute to altered pregnancy outcomes and adverse consequences in offspring. Conserved mechanisms of aging, as well as those unique to the reproductive system, underlie these phenotypes. The knowledge of such mechanisms will lead to development of therapeutics to extend female reproductive longevity and support endocrine function and overall health.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. Springer Nature America, Inc.)
Databáze: MEDLINE
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