Cognitive and kinematic markers of Ketamine effects in behaving non-human primates.

Autor: Pouget P; Institut du Cerveau, ICM, INSERM 1127, CNRS 7225 Sorbonne Université, Paris, France. Electronic address: pierre.pouget@icm-institute.org., Daye P; Institut du Cerveau, ICM, INSERM 1127, CNRS 7225 Sorbonne Université, Paris, France., Paré M; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada K7L 3N6. Electronic address: martin.pare@queensu.ca.
Jazyk: angličtina
Zdroj: European journal of pharmacology [Eur J Pharmacol] 2024 Dec 11, pp. 177185. Date of Electronic Publication: 2024 Dec 11.
DOI: 10.1016/j.ejphar.2024.177185
Abstrakt: Ketamine is widely used to probe cognitive functions relying on the properties of methyl-D-aspartate receptor (NMDAR) synaptic transmission. Numerous works have proved that cognitive performance and adjustments in the decision or perceptual domains are affected after ketamine injection in general circulation of primates. Here, we take advantage of that in the brain stem; horizontal saccade deceleration is controlled by glycine-NMDAR-gated current, while gamma-aminobutyric acid (GABA) current controls vertical deceleration to demonstrate that despite general circulation level manipulation of NMDAR synaptic transmission, the kinematic of the saccade appeared to be in the motor brainstem generator circuit differentially maintained. The results show that the deacceleration of the saccade elicited toward a horizontal target was substantially decreased, while the deacceleration of a vertical saccade remained largely unaffected. These results provide functional distinct markers for estimating cognitive and kinematic NMDAR-gated specificity acting in the pre-frontal cortex while maintaining specificity among the GABA circuit of drugs in general circulation.
Competing Interests: Declaration of Competing Interest P.P. and P.D. are co-inventors of several patents in eye movement tracking and co-founders of P3Lab company, which commercializes clinical eye-tracking systems. M.P. has nothing to disclose.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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