Assessing alcohol consumption across phosphatidylethanol levels using HDL-cholesterol as a predictor.

Autor:	Årving A; Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway., Hilberg T; Fürst Medisinsk Laboratorium, P.O. Box 158 Alnabru, Oslo 0614, Norway., Vigerust EW; Fürst Medisinsk Laboratorium, P.O. Box 158 Alnabru, Oslo 0614, Norway., Jørgenrud B; Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway., Bogstrand ST; Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway.; Department of Public Health Science, Institute of Health and Society, Faculty of Medicine, University of Oslo, P.O. Box 1089 Blindern, Oslo 0318, Norway., Mørland J; Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo 0213, Norway.; Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1039 Blindern, Oslo 0315, Norway., Høiseth G; Department of Forensic Sciences, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway.; Norwegian Centre for Addiction Research (SERAF), Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1039 Blindern, Oslo 0315, Norway.; Center for Psychopharmacology, Diakonhjemmet Hospital, P.O. Box 23 Vinderen, Oslo 0319, Norway.
Jazyk:	angličtina
Zdroj:	Alcohol and alcoholism (Oxford, Oxfordshire) [Alcohol Alcohol] 2024 Nov 18; Vol. 60 (1).
DOI:	10.1093/alcalc/agae085
Abstrakt:	Aims: Prior research has established a correlation between increases of High-Density Lipoprotein Cholesterol (HDL-C) levels and alcohol consumption. This study aimed to explore the association between phosphatidylethanol (PEth) levels and the amount of consumed ethanol, utilizing HDL-C as a surrogate marker on a population level. This endeavor offers an adjunct to other studies. Methods: PEth and HDL-C levels in 50 751 samples from 29 899 patients in Norway were measured simultaneously in whole blood and serum, respectively. Linear mixed model analyses were employed to assess HDL-C levels within different PEth intervals. Drawing on previous research indicating an increase of .0035 mmol/L in HDL-C per gram of pure ethanol consumed per day, and assuming no alcohol intake in the zero PEth group, we estimated mean daily ethanol intake at the group level for males in each PEth interval. Results: Results revealed a significant correlation between PEth and HDL-C levels (Spearman's rho = .385 for women, .420 for men, P < .001). Estimated mean HDL-C levels indicated higher alcohol consumption with increasing PEth. Specifically, men with PEth values in the .031-0.100 μmol/L (22-70 ng/ml) interval were estimated to consume approximately mean 20 grams of ethanol daily, while those in the .301-0.500 μmol/L (212-351 ng/ml) PEth interval had an estimated mean daily ethanol intake of 51 grams. Conclusions: The results from this study suggest an approximate estimation of mean daily amounts of consumed ethanol at group levels in different PEth intervals, based on previously shown correlation of ethanol consumption and HDL-C increase. (© The Author(s) 2024. Medical Council on Alcohol and Oxford University Press.)
Databáze:	MEDLINE
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