Risk of Pleural Recurrence in Early-Stage Non-small Cell Lung Cancer in Patients Treated With Surgery vs Stereotactic Ablative Radiotherapy.

Autor:	Grosu H; Pulmonary Medicine, MD Anderson Cancer Center, Houston, USA., Cabrera M; Pulmonary Medicine, MD Anderson Cancer Center, Houston, USA., Lizarraga Madrigal D; Internal Medicine, Instituto Tecnologico y de Estudios Superiores de Monterrey, Monterrey, MEX., Sainz Zuniga PV; Pulmonary Medicine, Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, MEX., Ost D; Pulmonary Medicine, MD Anderson Cancer Center, Houston, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Nov 12; Vol. 16 (11), pp. e73544. Date of Electronic Publication: 2024 Nov 12 (Print Publication: 2024).
DOI:	10.7759/cureus.73544
Abstrakt:	Background: Pleural recurrence has been reported after thoracic surgery and radiation treatment, and reports show that the surgery as the first treatment may be associated with an increased incidence of pleural recurrence. The main objective of this study was to compare the incidence of ipsilateral pleural recurrence in patients with non-small cell lung cancer (NSCLC) who underwent surgical resection or curative-intent radiotherapy. Methods: We performed a retrospective cohort study of patients aged 18 or older with stage I NSCLC who underwent surgical resection or curative-intent radiotherapy at our institution. The primary outcome of interest was an incidence of ipsilateral pleural recurrence at the time of first cancer recurrence. Secondary outcomes were the time of any first recurrence type of biopsy approach and the incidence of pleural recurrence. Results: Our cohort included 512 patients for whom complete data were available. Of these, 50 (9.7%) patients experienced recurrence and 51 died during the five-year follow-up since their first treatment. There was no difference in the incidence of ipsilateral pleural recurrence (P=0.348), the incidence of any recurrence (P=0.069), or time to first recurrence (P=0.088) between the curative intent surgery and radiotherapy groups. Biopsy type was not associated with recurrence. Conclusion: There was no difference in the incidence of ipsilateral pleural recurrence between the curative intent surgery and radiotherapy groups. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Review Board of MD Anderson Cancer Center issued approval 2023-0002. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Grosu et al.)
Databáze:	MEDLINE
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