A pilot study: relationship between Bisphenol A, Bisphenol-glucuronide and total 25 hydroxy vitamin D in maternal-child pairs in a South African population.
| Autor: | Gounden V; Department of Chemical Pathology, University of KwaZulu-Natal and National Health Laboratory Services, Inkosi Albert Luthuli Central Hospital, Durban, South Africa., Naidoo RN; Discipline of Occupational and Environmental Health, University of KwaZulu-Natal, Durban, South Africa., Chuturgoon A; Department of Medical Biochemistry, University of KwaZulu-Natal, Durban, South Africa. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Nov 28; Vol. 15, pp. 1108969. Date of Electronic Publication: 2024 Nov 28 (Print Publication: 2024). |
| DOI: | 10.3389/fendo.2024.1108969 |
| Abstrakt: | Introduction: Exposure to Bisphenol A (BPA) during early development particularly in-utero has been linked to a wide range of pathology. Over the last two decades the importance of vitamin D in maternal and child health has been highlighted. The aim of this pilot study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with 25-hydoxy vitamin D (25OHD) levels in South African mother-child pairs. Methods: Third-trimester serum maternal samples and matching cord blood samples were analyzed for BPA and BPA-g using liquid chromatography tandem mass spectrometry (LC-MS/MS) and 25OHD3 and 25OHD2 using high performance liquid chromatography. A total of 58 maternal and child pairs were analyzed. Results: More than fifty percent of maternal-child pairs were noted to be vitamin D deficient or insufficient using the Endocrine Society Practice guidelines cut-off of 50 nmol/L. Spearman rank correlation and Kruskal Wallis analysis did not show statistically significant relationship between cord 25OHD (total) and maternal and cord BPA-g concentrations. Analysis of covariance after controlling for confounders showed a significant relationship between cord BPA-g levels and cord 25OHD levels (p=0.03) as well as between maternal BPA-g levels (p=0.04) and cord total 25OHD levels (p=0.04). Discussion: The findings of the current study indicate a possible relationship with BPA/BPA-g and fetal/early infant Vitamin D levels that needs to be further investigated in this population. Competing Interests: The authors declare that study funding from AstraZeneca was received for the MACE study. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. (Copyright © 2024 Gounden, Naidoo and Chuturgoon.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|