Prevalence and factors associated with non-alcoholic fatty liver disease among women with polycystic ovary syndrome.

Autor:	Franciscatto ME; Universidade de Passo Fundo Faculty of Medicine Passo FundoRS Brazil Faculty of Medicine, Universidade de Passo Fundo, Passo Fundo, RS, Brazil., Taniguchi JB; Universidade de Passo Fundo Faculty of Medicine Passo FundoRS Brazil Faculty of Medicine, Universidade de Passo Fundo, Passo Fundo, RS, Brazil., Wohlenberg R; Universidade de Passo Fundo Faculty of Medicine Passo FundoRS Brazil Faculty of Medicine, Universidade de Passo Fundo, Passo Fundo, RS, Brazil., Riedi IL; Universidade de Passo Fundo Faculty of Medicine Passo FundoRS Brazil Faculty of Medicine, Universidade de Passo Fundo, Passo Fundo, RS, Brazil., Oppermann K; Universidade de Passo Fundo Faculty of Medicine Passo FundoRS Brazil Faculty of Medicine, Universidade de Passo Fundo, Passo Fundo, RS, Brazil.; Hospital São Vicente de Paulo Gynecology and Obstetrics Passo FundoRS Brazil Gynecology and Obstetrics, Hospital São Vicente de Paulo, Passo Fundo, RS, Brazil.
Jazyk:	angličtina
Zdroj:	Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2024 Dec 04; Vol. 46. Date of Electronic Publication: 2024 Dec 04 (Print Publication: 2024).
DOI:	10.61622/rbgo/2024rbgo81
Abstrakt:	Objective: To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS). Methods: A cross-sectional study was conducted with 53 patients with PCOS. The diagnosis of PCOS followed the Rotterdam criteria. The diagnosis of NAFLD was made through US showing hepatic steatosis, excluding significant alcohol consumption and chronic liver disease. The following variables were compared between the groups of women with and without NAFLD: age, race, anthropometric data, blood pressure levels, liver enzymes, glycemic and lipid profiles, total testosterone, presence of hirsutism, and metabolic syndrome (MS). Variables were compared between the groups using T-test, Mann-Whitney, and Chi-square tests. Results: Among 53 patients with PCOS, 50.9% had NAFLD. The NAFLD group had higher weight (p=0.003), BMI (p=0.001), waist circumference (p≤0.001), fasting glucose (p=0.021), HbA1C% (p=0.028), triglycerides (p=0.023), AST (p=0.004), ALT (p=0.001), higher prevalence of MS (p=0.004), and lower levels of HDL cholesterol (p=0.043). The other variables did not differ between the groups. Both groups were predominantly of caucasian race, and there was no significant difference in age. Conclusion: The prevalence of NAFLD among patients with PCOS was 50.9%. Metabolic and hepatic enzyme abnormalities were more prevalent in this group compared to the group without the disease. Obesity tripled the prevalence of NAFLD. Competing Interests: Conflicts to interest: none to declare. (© 2024. Federação Brasileira de Ginecologia e Obstetrícia. All rights reserved.)
Databáze:	MEDLINE
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