Antioxidant and anti-inflammatory activity of Euterpe oleracea Mart. (Açaí) seed bioproducts.

Autor: Previtalli-Silva H; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil, 4.365 - Manguinhos, CEP: 21040-360, Rio de Janeiro, RJ, Brazil.; Postgraduate Program in Tropical Medicine, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil, 4.365 - Manguinhos, CEP: 21040-360, Rio de Janeiro, RJ, Brazil., Hardoim DJ; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil, 4.365 - Manguinhos, CEP: 21040-360, Rio de Janeiro, RJ, Brazil., Banaggia RL; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil, 4.365 - Manguinhos, CEP: 21040-360, Rio de Janeiro, RJ, Brazil., Moragas-Tellis CJ; Laboratory of Natural Products for Public Health, Pharmaceutical Technology Institute (Farmanguinhos), Oswaldo Cruz Foundation, R. Sizenando Nabuco, 100 - Manguinhos, CEP 21041-250, Rio de Janeiro, Brazil., Chagas MDSDS; Laboratory of Natural Products for Public Health, Pharmaceutical Technology Institute (Farmanguinhos), Oswaldo Cruz Foundation, R. Sizenando Nabuco, 100 - Manguinhos, CEP 21041-250, Rio de Janeiro, Brazil., Behrens MD; Laboratory of Natural Products for Public Health, Pharmaceutical Technology Institute (Farmanguinhos), Oswaldo Cruz Foundation, R. Sizenando Nabuco, 100 - Manguinhos, CEP 21041-250, Rio de Janeiro, Brazil., Dias-Silva TS; Laboratory of Medicinal Chemistry, Chemistry Institute, UFRRJ, BR-465, Km 47- Seropédica, CEP. 23.897-000, Rio de Janeiro, RJ, Brazil., Calabrese KDS; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil, 4.365 - Manguinhos, CEP: 21040-360, Rio de Janeiro, RJ, Brazil., Cardoso FO; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil, 4.365 - Manguinhos, CEP: 21040-360, Rio de Janeiro, RJ, Brazil.
Jazyk: angličtina
Zdroj: Heliyon [Heliyon] 2024 Nov 19; Vol. 10 (23), pp. e40510. Date of Electronic Publication: 2024 Nov 19 (Print Publication: 2024).
DOI: 10.1016/j.heliyon.2024.e40510
Abstrakt: Euterpe oleracea Mart. is a tropical palm tree native to the Amazon region. Its fruit, commonly known as açaí, has gained widespread recognition for its therapeutic potential, driving the expansion of pharmacological studies to validate its traditional uses. Leveraging açaí seeds in research not only mitigates environmental impacts but also enables the identification of bioactive compounds with potential pharmacological applications, including drug development. Thus, the present work aims to investigate the antioxidant and anti-inflammatory activities of the hydroalcoholic extract and the ethyl acetate, hexane, dichloromethane and aqueous fractions of açaí seeds in vitro. The extract/fractions from açaí contained a significant amount of flavonoids, such as catechins and procyanidins, according to LC-MS/MS. These bioproducts showed significant antioxidant activity, with emphasis on the ethyl acetate fraction (FRAP: 4516.00 ± 58.07 Eq Trolox/g compound; DPPH: IC 50 3.93 ± 0.26 μg/. mL; ABTS • + : IC 50 34.65 ± 0.35 μg/mL). In addition, the compounds exhibited an anti-inflammatory action on LPS-stimulated peritoneal macrophages, with the dichloromethane fraction showing the more comprehensive inhibitory effects on NO, IL-12 and IFN-γ production, especially in the concentration of 500 μg/mL. E. oleracea seeds extract/fractions had no cytotoxic effect on peritoneal macrophages (IC 50  > 500 μg/mL). These findings suggest that E. oleracea seed-derived bioproducts hold significant promise as safe and effective agents for the development of novel antioxidant and anti-inflammatory therapies targeting a variety of inflammatory pathologies.
Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Cardoso reports equipment, drugs, or supplies was provided by Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State. Calabrese reports financial support, administrative support, article publishing charges, and equipment, drugs, or supplies were provided by 10.13039/501100024786Oswaldo Cruz Institute. Previtalli-Silva reports financial support was provided by Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil). Calabrese reports that is research productivity fellow by 10.13039/501100002923National Scientific and Technical Research Council (CNPq). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
Databáze: MEDLINE
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