Case Report: A Young Woman Diagnosed With Overlap Syndrome of Systemic Sclerosis and Ankylosing Spondylitis.

Autor: Li C; Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.; Department of Rheumatology, Fangshan Hospital, Beijing University of Chinese Medicine, Beijing, China., Jin D; Department of Rheumatology, Weifang People's Hospital, Weifang, Shandong, China., Gong YF; Department of Rheumatology, Weifang People's Hospital, Weifang, Shandong, China., Liu HX; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China., Guan YW; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China., Li SG; Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2024 Dec; Vol. 27 (12), pp. e15427.
DOI: 10.1111/1756-185X.15427
Abstrakt: This case report describes a rare occurrence of a 25-year-old female diagnosed with both systemic sclerosis (SSc) and ankylosing spondylitis (AS), two distinct autoimmune diseases. The patient presented with a combination of symptoms, including progressive skin tightening, lumbosacral pain, and Raynaud's phenomenon, which complicated the diagnosis. Despite the challenges posed by the coexistence of SSc and AS, a multidisciplinary treatment approach involving corticosteroids, immunosuppressants, and supportive therapies led to significant clinical improvement. Over the course of 3 weeks, the patient's Rodnan Skin Score improved from 18 to 11, and her pain and overall disease activity were markedly reduced. Although skin sclerosis showed substantial improvement, pulmonary involvement remains a concern that requires long-term monitoring. This case highlights the complexities in diagnosing and managing overlap syndromes, emphasizing the need for personalized treatment strategies and further investigation into the underlying genetic and immunological mechanisms.
(© 2024 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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