Cellular Interactions and Biological Effects of Silk Fibroin: Implications for Tissue Engineering and Regenerative Medicine.

Autor: Zhu J; School of Medicine, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, 210000, China., Du Y; School of Medicine, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, 210000, China., Backman LJ; Department of Medical and Translational Biology, Anatomy, Umeå University, Umeå, 90187, Sweden.; Department of Community Medicine and Rehabilitation, Section of Physiotherapy, Umeå University, Umeå, 90187, Sweden., Chen J; School of Medicine, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, 210000, China.; Department of Ophthalmology, Zhongda Hospital, Southeast University, Nanjing, 210009, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, 310000, China., Ouyang H; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, 310000, China.; Department of Sports Medicine of the Second Affiliated Hospital, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310000, China., Zhang W; School of Medicine, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, 210000, China.; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, 310000, China.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Dec 12, pp. e2409739. Date of Electronic Publication: 2024 Dec 12.
DOI: 10.1002/smll.202409739
Abstrakt: Silk fibroin (SF), the core structural protein derived from Bombyx mori silk, is extensively employed in tissue engineering and regenerative medicine due to its exceptional mechanical properties, favorable biocompatibility, tunable biodegradability, and versatile processing capabilities. Despite these advantages, current research predominantly focuses on SF biomaterials as structural scaffolds or drug carriers, often overlooking their potential role in modulating cellular behavior and tissue regeneration. This review aims to present a comprehensive overview of the inherent biological effects of SF biomaterials, independent of any exogenous biomolecules, and their implications for various tissue regeneration. It will cover in vitro cellular interactions of SF with various cell types, including stem cells and functional tissue cells such as osteoblasts, chondrocytes, keratinocytes, endothelial cells, fibroblasts, and epithelial cells. Moreover, it will summarize in vivo immune responses, cellular responses, and tissue regeneration following SF implantation, specifically focusing on vascular, bone, skin, cartilage, ocular, and tendon/ligament regeneration. Furthermore, it will address current limitations and future perspectives in the design of bioactive SF biomaterials. A comprehensive understanding of these cellular interactions and the biological effects of SF is crucial for predicting regenerative outcomes with precision and for designing SF-based biomaterials tailored to specific properties, enabling broader applications in regenerative medicine.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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