Carob (Ceratonia siliqua) leaves: A comprehensive analysis of bioactive profile and health-promoting potential of an untapped resource.

Autor: Serio S; Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy; PhD Program in Drug Discovery and Development, University of Salerno, 84084 Fisciano, Salerno, Italy., Santoro V; Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy., Celano R; Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy., Fiore D; Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy., Proto MC; Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy., Corbo F; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy., Clodoveo ML; Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', 70124 Bari, Italy., Tardugno R; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', 70125 Bari, Italy., Piccinelli AL; Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy. Electronic address: apiccinelli@unisa.it., Rastrelli L; Department of Pharmacy, University of Salerno, 84084 Fisciano, Salerno, Italy; National Biodiversity Future Center (NBFC), 90133 Palermo, PA, Italy.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Dec 09; Vol. 468, pp. 142392. Date of Electronic Publication: 2024 Dec 09.
DOI: 10.1016/j.foodchem.2024.142392
Abstrakt: Carob is a resilient plant with ecological and nutritional significance. A comprehensive study of Ceratonia siliqua leaves (CSL) was conducted to explore its chemical composition and health-promoting potential, aiming at improving the carob-crop sustainability through valorization of this untapped co-product. UHPLC-DAD-HRMS/MS quali-quantitative profiling of CSL revealed high levels of n-galloylated glucoses (129-196 mg g -1 ) and flavonol-glycosides (36-42 mg g -1 ), with siliquapyranone (39-56 mg g -1 ), 1,2,3,6-tetragalloylglusose (47-69 mg g -1 ) and myricitrin (27-33 mg g -1 ) as main markers. Highest bioactive content and antioxidant capacity (5.0 and 3.1 TEAC) was obtained during pods harvesting. Besides significant antioxidant potential, CSL exhibited strong-high inhibitory activity against α-glucosidase, acetylcholinesterase and butyrylcholinesterase (IC 50 , 0.51, 13.5 and 58.0 μg mL -1 , respectively). 1,2,3,6-tetragalloylglusose and siliquapyranone are the main contributors to antioxidant and α-glucosidase inhibitory capacities. Excellent ability of extract and 1,2,3,6-tetragalloylglusose (IC 50 , 0.05 μM) in selectively inhibiting α-glucosidase, make them promising candidates to manage hyperglycemia with fewer side effects.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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