Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex.

Autor:	Baretella O; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.; Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland., Blum MR; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.; Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland., Abolhassani N; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.; Department of Epidemiology and Health Systems, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland., Alwan H; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland., Wildisen L; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland., Del Giovane C; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland., Tal K; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland., Moutzouri E; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.; Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland., Åsvold BO; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Cappola AR; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA., Gussekloo J; LUMC Center for Medicine for older people, Department of Public Health and Primary Care, and Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Iacoviello M; Cardiology Unit, Emergency and Organ Transplantation Department, University of Bari, Bari, Italy., Iervasi G; National Research Council, Institute of Clinical Physiology, Tuscany Region G. Monasterio Foundation, Pisa, Italy., Imaizumi M; Department of Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan., Weiler S; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH, Zurich, Switzerland.; Institute of Primary Care, University and University Hospital Zurich, Zurich, Switzerland., Razvi S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Sgarbi JA; Division of Endocrinology, Faculdade de Medicina de Marília, Marília, Brazil., Völzke H; Institute for Community Medicine, SHIP/Clinical-Epidemiological Research, University Medicine Greifswald, Germany., Brown SJ; Medical School, University of Western Australia, Crawley, Western Australia; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia., Walsh JP; Medical School, University of Western Australia, Crawley, Western Australia; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia., Vaes B; Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium., Yeap BB; Medical School, University of Western Australia, Perth, Australia; Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Australia., Dullaart RPF; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Ceresini G; Unit of Internal Medicine and Oncological Endocrinology, University of Parma, University Hospital Parma, Parma, Italy., Ferrucci L; National Institutes on Aging, Longitudinal Studies Section, Baltimore, USA., Aujesky D; Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland., Peeters RP; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Bauer DC; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.; Departments of Medicine and Epidemiology & Biostatistics, University of California, San Francisco, USA., Feller M; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland., Rodondi N; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.; Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Dec 12. Date of Electronic Publication: 2024 Dec 12.
DOI:	10.1210/clinem/dgae860
Abstrakt:	Context: Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events. Objective: To assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex. Design and Setting: Pooled individual participant data analysis of large prospective cohort studies from the Thyroid Studies Collaboration. Participants: Aged 18 to 103 years with SHypo (TSH >4.50 mU/l, normal fT4) and SHyper (TSH <0.45 mU/l, normal fT4) vs. euthyroid (TSH 0.45-4.50 mU/l). Interventions: None as this is an observational study. Main Outcome Measures: cvRFs, i.e. blood pressure, lipid levels, hs-CRP. Results: Of 69,006 participants (mean age 62 years, 55% women, 25% current smokers) from 16 international cohorts, 3,748 (5.4%) had SHypo and 3,428 (5.0%) had SHyper. In both women and men, systolic and diastolic BP were similar regardless of thyroid status. Exceptions were lower diastolic BP in women with SHyper compared to euthyroids (adjusted mean difference [aMD] -1.3 mmHg, 95%CI -2.0 to -0.5), and lower systolic BP in men with SHyper compared to euthyroids (aMD -3.1 mmHg, 95%CI -4.8 to-1.4). In both women and men, lipid levels (total, HDL, LDL cholesterol, triglycerides) and hs-CRP were similar regardless of thyroid status. The only exception were women with SHyper who had a lower LDL cholesterol compared to euthyroids (aMD -0.17 mmol/l, 95%CI -0.29 to -0.05). Conclusions: Participants with ScTD and euthyroids have similar cvRFs and differences are arguably too small to explain the increased cardiovascular risk in ScTD observed in previous studies. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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