An excitatory neural circuit for descending inhibition of itch processing.

Autor:	Wu GY; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China. Electronic address: wgy009@tmmu.edu.cn., Li RX; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Liu J; Department of Foreign Languages, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Sun L; Southwest Hospital, Army Medical University, Chongqing 400038, China., Yi YL; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Yao J; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Tang BQ; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Wen HZ; Department of Neurobiology, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Chen PH; Department of Neurobiology, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Lou YX; Department of Neurobiology, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Li HL; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China. Electronic address: lihongli@tmmu.edu.cn., Sui JF; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China. Electronic address: jfsui2003@163.com.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Dec 24; Vol. 43 (12), pp. 115062. Date of Electronic Publication: 2024 Dec 11.
DOI:	10.1016/j.celrep.2024.115062
Abstrakt:	Itch serves as a self-protection mechanism against harmful external agents, whereas uncontrolled and persistent itch severely influences the quality of life of patients and aggravates their diseases. Unfortunately, the existing treatments are largely ineffective. The current difficulty in treatment may be closely related to the fact that the central neural mechanisms underlying itch processing, especially descending inhibition of itch, are poorly understood. Here, we demonstrate that an excitatory descending neural circuit from rostral anterior cingulate cortex pyramidal (rACC Py ) neurons to periaqueductal gray GABAergic (PAG GABA ) neurons plays a key role in the inhibition of itch. The activity of itch-tagged rACC Py neurons decreases during the itch-evoked scratching period. Artificial activation or inhibition of the neural circuits significantly impairs or enhances itch processing, respectively. Thus, an excitatory neural circuit is identified as playing a crucial inhibitory role in descending regulation of itch, suggesting that it could be a potential target for treating itch. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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