Healing Effect of Hypericum perforatum in Burn Injuries.
| Autor: | Hamedi ZS; Division of Hematology, Oncology and Palliative Care, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia., Manafi A; Department of Anesthesiology, Arrowhead Regional Medical Center, Colton, California., Hashemi SS; Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Mehrabani D; Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Comparative and Experimental Medicne Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Li Ka Shing Center for Health Research and Innovation, University of Alberta, Edmonton, AB, Canada., Seddighi A; Department of Molecular Biology, Universität Wien, Wien, Austria.; Department of Genetics, Tehran Branch, Islamic Azad University, Tehran, Iran., Tanideh N; Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Mokhtari M; Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of plastic surgery [World J Plast Surg] 2024; Vol. 13 (3), pp. 57-65. |
| DOI: | 10.61186/wjps.13.3.57 |
| Abstrakt: | Background: Burn injury is still the leading cause of mortality and morbidity in burn patients. We comapred healing effect of Hypericum perforatum , silver sulfadiazine and alpha ointments on burn injuries in rat model. Methods: Sixty female Sprague-Dawley rats in an animal experimental study were randomly divided to 5 equal groups as H. perforatum , silver sulfadiazine and (SSD), alpha, gel base and the burn injury left untreated. Wounds were assessed macroscopically and histologic after burn injury and on days 7 th , 14 th and 21 st after treatments. Results: Burn wounds decreased in size on day 7 th in H. perforatum group ( P <0.01). Regarding scoring the inflammation, re-epithelialization, angiogenesis, formation of granulation tissue and number of macrophage, the best scores were visible in H. perforatum group, and the worst in the gel base and the burn injury left untreated ( P <0.01). Conclusions: H. perforatum was shown to significantly induce re-epithelialization, angiogenesis and granulation tissue and decrease the inflammation resulting into a healing process in burn wounds. As H. perforatum is inexpensive and an easily available herbal medicine, it can be considered as a therapeutic of choice to ameliorate burn injuries. Competing Interests: The authors of the current manuscript certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript. |
| Databáze: | MEDLINE |
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