Terahertz Wave Alleviates Comorbidity Anxiety in Pain by Reducing the Binding Capacity of Nanostructured Glutamate Molecules to GluA2.

Autor:	Song Z; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China., Sun Y; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China., Liu P; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China., Ruan H; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China., He Y; School of Safety Engineering, North China Institute of Science and Technology, Hebei 065201, China., Yin J; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China., Xiao C; School of Life Sciences, Tsinghua University, Beijing 100081, China., Ma J; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China., Yu Y; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China.; School of Life Science and Technology and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China., Wang S; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China., Gong Y; School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China., Lin ZW; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China., Zhang Z; Division of Life Sciences and Medicine, Department of Anesthesiology, the First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China., Chang C; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China.; School of Physics, Peking University, Beijing 100081, China., Yang M; School of Life Sciences, Tsinghua University, Beijing 100081, China.
Jazyk:	angličtina
Zdroj:	Research (Washington, D.C.) [Research (Wash D C)] 2024 Dec 11; Vol. 7, pp. 0535. Date of Electronic Publication: 2024 Dec 11 (Print Publication: 2024).
DOI:	10.34133/research.0535
Abstrakt:	Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy and carry a risk of side effects. Here, we report a terahertz (THz, 10 12 Hz) wave stimulation (THS) technique, which exerts nonthermal, long-term modulatory effects on neuronal activity by reducing the binding between nano-sized glutamate molecules and GluA2, leading to the relief of pain and comorbid anxiety-like behaviors in mice. In mice with co-occurring anxiety and chronic pain induced by complete Freund's adjuvant (CFA) injection, hyperactivity was observed in glutamatergic neurons in the anterior cingulate cortex (ACC Glu ). Using whole-cell recording in ACC slices, we demonstrated that THS (34 THz) effectively inhibited the excitability of ACC Glu . Moreover, molecular dynamics simulations showed that THS reduced the number of hydrogen bonds bound between glutamate molecules and GluA2. Furthermore, THS target to the ACC in CFA-treatment mice suppressed ACC Glu hyperactivity and, as a result, alleviated pain and anxiety-like behaviors. Consistently, inhibition of ACC Glu hyperactivity by chemogenetics mimics THS-induced antinociceptive and antianxiety behavior. Together, our study provides evidence for THS as an intervention technique for modulating neuronal activity and a viable clinical treatment strategy for pain and comorbid anxiety. Competing Interests: Competing interests: The authors declare that they have no competing interests. (Copyright © 2024 Zihua Song et al.)
Databáze:	MEDLINE
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