Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants.

Autor: Jiang S; Division of Neonatology, University of California San Diego, La Jolla, CA, USA.; Division of Neonatology, Children's Hospital of Fudan University, Shanghai, China., Cui X; Division of Neonatology, Stanford University, Stanford, CA, USA.; California Perinatal Quality Care Collaborative, Stanford, CA, USA., Katheria A; Division of Neonatology, University of California San Diego, La Jolla, CA, USA.; Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA, USA., Finer NN; Division of Neonatology, University of California San Diego, La Jolla, CA, USA.; Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA, USA., Bennett MV; Division of Neonatology, Stanford University, Stanford, CA, USA.; California Perinatal Quality Care Collaborative, Stanford, CA, USA., Profit J; Division of Neonatology, Stanford University, Stanford, CA, USA.; California Perinatal Quality Care Collaborative, Stanford, CA, USA., Lee HC; Division of Neonatology, University of California San Diego, La Jolla, CA, USA. henrylee@health.ucsd.edu.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11.
DOI: 10.1038/s41372-024-02194-w
Abstrakt: Objective: To assess the relationship between 5-min oxygen saturation (SpO2) and outcomes in extremely preterm infants.
Study Design: This cohort study included infants ≤28 weeks' gestation across nine hospitals from 2020 to 2022. Death and / or severe intraventricular hemorrhage (IVH) were compared between infants with 5-min SpO2 < 80% and 80-100% using Poisson regression models. Receiver Operating Characteristic (ROC) curve and optimal breakpoint analysis were used to estimate the optimal breakpoint of 5-min SpO2 in relation to outcomes.
Result: Of 390 infants, 184 (47.2%) had 5-min SpO2 < 80%. A 5-min SpO2 < 80% was independently associated with increased risks of death and / or severe IVH, early death, and severe IVH. ROC analysis of 5-min SpO2 identified optimal breakpoint at 81-85%, above which no additional benefit in outcomes was observed.
Conclusion: Our findings support the current recommendation of 5-min SpO2 target of ≥80% for extremely preterm infants.
Competing Interests: Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All methods were performed in accordance with relevant guidelines and regulations. This data-only study was approved by the Institutional Review Board of Stanford University (protocol 1811082), with an exemption from the requirement for informed consent.
(© 2024. The Author(s).)
Databáze: MEDLINE
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