Interactions between vitamin D deficiency and inflammation on diabetes risk: data from 336,500 UK Biobank adults: Short title Vitamin D Deficiency, Inflammation, and Diabetes.

Autor:	Kositsawat J; Center on Aging, University of Connecticut, Farmington, CT. Electronic address: kositsawat@uchc.edu., Zhao S; The Cato T. Laurencin Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, United States., Kuchel GA; Center on Aging, University of Connecticut, Farmington, CT., Barry LC; Center on Aging, University of Connecticut, Farmington, CT., Fortinsky RH; Center on Aging, University of Connecticut, Farmington, CT., Kirk B; Department of Medicine, Western Health, Melbourne Medical School, University of Melbourne, St Albans, Melbourne, VIC, Australia; Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, Melbourne, VIC, Australia., Duque G; Bone, Muscle and Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Dr. Joseph Kaufmann Chair in Geriatric Medicine, Department of Medicine, McGill University, Montreal, QC, Canada., Kuo CL; The Cato T. Laurencin Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, United States.
Jazyk:	angličtina
Zdroj:	The journal of nutrition, health & aging [J Nutr Health Aging] 2024 Dec 10; Vol. 29 (2), pp. 100446. Date of Electronic Publication: 2024 Dec 10.
DOI:	10.1016/j.jnha.2024.100446
Abstrakt:	Objectives: Findings regarding the effects of vitamin D supplementation on diabetes risk are inconclusive. Because inflammation and vitamin D levels are interconnected, we hypothesized that higher inflammation levels moderate the effects of vitamin D deficiency on diabetes risk. Design, Setting, Participants, and Measurements: UK Biobank participants without pre-existing diabetes at baseline were included (N = 336,500). We first linked vitamin D and C-reactive protein (CRP; inflammation measure) levels with incident diabetes during a mean follow-up of 13.5 years (SD = 1.9). Then, we investigated the moderation effect of CRP on the associations between vitamin D deficiency (<10 ng/mL) and incident diabetes and performed subgroup analyses according to age (<60 vs. ≥60 years) and frailty status (frail; pre-frail; non-frail). Multivariate analyses were conducted using restricted cubic spline Cox proportional hazards regression models. Results: Lower vitamin D and higher CRP levels were significantly associated with an increased risk of diabetes during follow-up. There was a significant interaction between vitamin D deficiency and CRP on incident diabetes (p < 0.001). In participants with higher levels of CRP, the hazard ratio of developing diabetes comparing participants who had vitamin D deficiency to those who did not was lower than that in participants with lower levels of CRP. The moderation effect of CRP was similar between younger and older adults but was stronger in frail or pre-frail older adults than in non-frail older adults. Conclusion: Our findings indicate that the effect of vitamin D deficiency on incident diabetes may be affected by inflammation. This finding may explain the inconsistent results from vitamin D supplementation trials. Vitamin D supplementation without considering the potential impact of inflammation might prove unsatisfactory. Competing Interests: Declaration of competing interest We have no conflicting interests to disclose. (Published by Elsevier Masson SAS.)
Databáze:	MEDLINE
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