Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study.

Autor:	Boughanem H; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Torres-Peña JD; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Arenas-de Larriva AP; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Romero-Cabrera JL; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Gómez-Luna P; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Martín-Piedra L; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Rodríguez-Cantalejo F; Biochemical Laboratory, Reina Sofia University Hospital, 14004 Córdoba, Spain., Tinahones FJ; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, Spain.; Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Malaga, Spain., Yubero Serrano EM; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Soehnlein O; Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), University of Münster, 48149 Münster, Germany., Perez-Martinez P; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., Delgado-Lista J; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain., López-Miranda J; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain.; Department of Medical and Surgical Sciences, Universidad de Cordoba, 14004 Cordoba, Spain.; Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.; CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	European heart journal [Eur Heart J] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11.
DOI:	10.1093/eurheartj/ehae836
Abstrakt:	Background and Aims: Several studies have supported the role of innate immune system as a key factor in the sterile inflammation underlying the pathophysiology of atherosclerosis in mice. However, its involvement in humans remains unclear. This study aimed to explore the association between neutrophil count, and the intima-media thickness of common carotid arteries (IMT-CC), as well as the potential impact of long-term dietary interventions on these associations. Methods: A comprehensive analysis was conducted within the framework of the CORDIOPREV study, a long-term secondary prevention study involving dietary interventions with either a Mediterranean or a low-fat diet. The study evaluated the relationship between absolute neutrophil count and neutrophil-related ratios with IMT-CC at baseline and after 5 and 7 years of dietary intervention. Results: At baseline, patients in the highest tertile of neutrophil count had a higher IMT-CC and number of carotid plaques, when compared to lowest tertile (P < .01 and P < .05, respectively). Logistic regression analyses supported this association. Elevated neutrophil count, neutrophil-to-erythrocyte ratio, and neutrophil-to-HDL ratio were associated with an increased likelihood of having an IMT-CC >.9 mm {odds ratio (OR) 1.17 [95% confidence interval (CI) 1.04-1.35], OR 2.21 (95% CI 1.24-4.12), and OR 1.96 (95% CI 1.09-3.55), respectively}, after adjustment for all variables, which was corroborated by linear regression. Furthermore, a linear mixed-effect model analysis from a longitudinal analysis spanning 5 and 7 years revealed an increase in 1 unit of neutrophils/μl at these time points was associated with a mean increase of .004 (.002) mm in the IMT-CC (P = .031) after adjustment for all variables. Interestingly, in patients exhibiting regression in IMT-CC after 7 years of follow-up, those following a Mediterranean diet showed a significant decrease in neutrophil count after 5 and 7 years (both with P < .05), compared to baseline. Conclusions: These findings suggest that neutrophils may represent a promising target for preventing atherosclerosis. A Mediterranean diet could serve as an effective dietary strategy to reduce neutrophil levels and potentially slow the progression of atherosclerosis, offering a new neutrophil-reducing therapy concept. Further research is essential to gain deeper insights into the role of neutrophils in the pathophysiology of atherosclerotic cardiovascular disease in humans. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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