Hypersensitive intercellular responses of endometrial stromal cells drive invasion in Endometriosis.

Autor: Chen CW; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Chavez JB; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Kumar R; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Go VA; Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Pant A; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Jain A; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Polusani SR; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Hart MJ; Center for Innovative Drug Discovery, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Robinson RD; Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Gaczynska M; Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Osmulski P; Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Kirma NB; Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, United States., Nicholson BJ; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, United States.
Jazyk: angličtina
Zdroj: ELife [Elife] 2024 Dec 11; Vol. 13. Date of Electronic Publication: 2024 Dec 11.
DOI: 10.7554/eLife.94778
Abstrakt: Endometriosis is a debilitating disease affecting 190 million women worldwide and the greatest single contributor to infertility. The most broadly accepted etiology is that uterine endometrial cells retrogradely enter the peritoneum during menses, implant and form invasive lesions in a process analogous to cancer metastasis. However, over 90% of women suffer retrograde menstruation, but only 10% develop endometriosis, and debate continues as to whether the underlying defect is endometrial or peritoneal. Processes implicated in invasion include: enhanced motility; adhesion to, and formation of gap junctions with, the target tissue. Endometrial stromal (ESCs) from 22 endometriosis patients at different disease stages show much greater invasiveness across mesothelial (or endothelial) monolayers than ESCs from 22 control subjects, which is further enhanced by the presence of EECs. This is due to enhanced responsiveness of endometriosis ESCs to the mesothelium, which induces migration and gap junction coupling. ESC-PMC gap junction coupling is shown to be required for invasion, while coupling between PMCs enhances mesothelial barrier breakdown.
Competing Interests: CC, JC, RK, VG, AP, AJ, SP, MH, RR, MG, PO The other authors declare that no competing interests exist. NK Nameer B Kirma, co-founder and shareholder of Hear Biotech Inc., developing a diagnostic for endometriosis in part based on these findings. BN Bruce J Nicholson, co-founder and shareholder of Hear Biotech Inc., developing a diagnostic for endometriosis in part based on these findings.
(© 2024, Chen et al.)
Databáze: MEDLINE