Robinin Isolated from Solanum asperum Exhibits Pharmacological Actions in the Central Nervous System of Adult Zebrafish (Danio rerio).

Autor: Lemos CG; Universidade Estadual do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Wlisses da Silva A; Universidade Estadual do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Maciel JB; Universidade Estadual do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Ferreira MKA; Universidade Estadual do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Nunes da Rocha M; Universidade Estadual do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Marinho MM; Universidade Estadual do Ceara - Campus do Itaperi, Chemistry, Silas munguba, fortaleza, BRAZIL., Marinho ES; Universidade Estadual do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Pinto FDCL; Universidade Federal do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Loiola OD; Universidade Federal do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., de Castro Gomes AF; Universidade do Minho, Biologia, braga, braga, PORTUGAL., de Menezes JESA; Universidade Estadual do Ceara, Chemistry, Silas munguba, fortaleza, BRAZIL., Dos Santos HS; State University of Acaraú Valley, Chemistry, RODOVIA CE 040, Casa 21 quadra 13, 61760000, Aquiraz, BRAZIL.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Dec 11, pp. e202402173. Date of Electronic Publication: 2024 Dec 11.
DOI: 10.1002/cbdv.202402173
Abstrakt: This study investigated the anxiolytic, anticonvulsant and memory preservation effects of the flavonoid robinin. The compound, administered at doses of 4, 20 and 40 mg/kg, did not show toxicity after 96 hours of monitoring. In behavioral experiments with zebrafish, robinin did not cause significant changes in motor functions, but it impairs locomotor activity and demonstrates anxiolytic properties, evidenced by the increase in the time spent in the clean zone of the protector. A minimum effective dose (4 mg/kg) was blocked by flumazenil, providing an interaction with GABAA receptors and decreasing an anxiolytic profile similar to that of diazepam, without causing sedation. In addition, a dose of 40 mg/kg was able to reverse seizures, increasing the latency to enter the seizure stages, an effect that was also blocked by flumazenil. Robinin (40 mg/kg) also prevented memory variation in an inhibitory avoidance test. In silico ADME tests indicated that robinine presents gradual intestinal absorption and low distribution in the central nervous system. In molecular docking, the compound was exposed in the layer with CAII and GABAA receptors, corroborating the anxiolytic and anticonvulsant effects.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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