Systemic Treatment Followed by Radical Resection Combined with Intestinal Autotransplantation (RRCIA) for Locally Advanced Pancreatic Cancer: A Retrospectively Observational and Prospectively Validated Study.

Autor:	Qiao G; Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Bai X; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Pancreatic Disease of Zhejiang Province, Hangzhou, China., Li X; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhang Q; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Pancreatic Disease of Zhejiang Province, Hangzhou, China., Chen Y; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Ma T; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wu G; Department of Colorectal Surgery and Intestinal Transplant Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Xiao W; Department of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Sun K; Department of Pathology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Jiang T; Department of Ultrasound, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Su X; Department of Nuclear Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Morse MA; Department of Duke Cancer Center, Duke University Medical Center, Durham, United States., Liang T; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Pancreatic Disease of Zhejiang Province, Hangzhou, China.
Jazyk:	angličtina
Zdroj:	Annals of surgery [Ann Surg] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11.
DOI:	10.1097/SLA.0000000000006600
Abstrakt:	Objective: The present study aimed to assess the efficacy of this approach and establish the criteria that identify LAPC patients who may achieve survival benefits from RRCIA. Summary Background Data: Surgical resection for locally advanced pancreatic cancer (LAPC) remains challenging and associated with high morbidity and mortality, especially for surgery with major arterial reconstruction. We previously showed the feasibility and safety of Radical Resection Combined with Intestinal Autotransplantation (RRCIA) after systemic treatment. Methods: A retrospectively observational and prospectively validated study with three cohorts was conducted using multiple treatments. Overall survival (OS) and progression-free survival (PFS) were compared for both analyses. Propensity-score matching (PSM) and stabilized inverse probability of treatment weighting (IPTW) were performed to adjust for potential confounders. Results: Among 208 patients with LAPC we identified 48 who underwent systemic treatment followed by RRCIA. Using Propensity-score matching (PSM) and stabilized inverse probability of treatment weighting (IPTW) analyses, we observed that patients who underwent RRCIA had better overall and progression free survival compared with patients who did not have surgery (PSM cohort: median OS: 25.8 mo vs. 14.2 mo, P=0.0031, and IPTW cohort: median OS: 23.2 mo vs. 15.4 mo, P=0.0069) and PFS (PSM cohort: median PFS: 13.3 mo vs. 7.0 mo, P=0.0246, and IPTW cohort: median OS: 13.3 mo vs. 8.8 mo, P=0.002). Further prospective analysis showed that patients who received systemic treatment followed by RRCIA were associated with improved OS and PFS compared with patients who were eligible but did not receive RRCIA (median OS: 22.6 mo vs. 18.2 mo, P=0.035; median PFS: 13.2 mo vs. 10.3 mo, P=0.0412). Moreover, stratified and multivariable analysis demonstrated that preoperative CA19-9 normalization and duration of initial treatment over 8 cycles were predictors for precise selection of patients who would benefit from RRCIA. Meanwhile, adjuvant therapy after RRCIA was a significant factor for improving survival. Conclusion: This study suggests that RRCIA appears to be effective and associated with improved outcomes for LAPC patients with favorable response to systemic treatment. LAPC patients Should have at least 8 cycles of systemic treatment and CA19-9 normalization to be considered for RRCIA. Competing Interests: The authors report no conflicts of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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