Disagreement on foundational principles of biological aging.

Autor:	Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Anderson B; Articulate Ventures, St Louis, MO 63124, USA., Barlit H; Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA., Barré B; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Beck S; Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA., Behrouz B; Vincere Biosciences Inc., Cambridge, MA 02142, USA., Belsky DW; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.; Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY 10032, USA., Chaix A; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA., Chamoli M; Buck Institute for Research on Aging, Novato, CA 94945, USA., Chen BH; California Pacific Medical Center Research Institute, Sutter Health, San Francisco, CA 94143, USA., Cheng K; University of California-Los Angeles, Los Angeles, CA 90095, USA., Chuprin J; University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Churchill GA; The Jackson Laboratory, Bar Harbor, ME 04609, USA., Cipriano A; Stanford University School of Medicine, Stanford, CA 94305, USA., Colville A; Stanford University School of Medicine, Stanford, CA 94305, USA., Deelen J; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne 50931, Germany., Deigin Y; YouthBio Therapeutics Inc., Seattle, WA, USA., Edmonds KK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Cambridge, MA 02139, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., English BW; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Fang R; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA., Florea M; Harvard Medical School, Boston, MA 02115, USA., Gershteyn IM; ImmuVia Inc and Medical University of South Carolina, Charleston, SC 29425, USA., Gill D; Altos Labs Cambridge Institute of Science, Cambridge, CB21 6GP, United Kingdom., Goetz LH; Net/Bio, Inc., Beverly Hills, CA 90212, USA., Gorbunova V; Departments of Biology and Medicine, University of Rochester, Hutchison Hall, Rochester, NY 14627, USA., Griffin PT; Harvard Medical School, Boston, MA 02115, USA., Horvath S; Altos Labs, Cambridge, United Kingdom., Borch Jensen M; Gordian Biotechnology, San Francisco, CA, USA., Jin X; The Scripps Research Institute, La Jolla, CA 92037, USA., Jovanovska S; Utrecht University, Utrecht, The Netherlands., Kajderowicz KM; Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Kasahara T; Tohoku University, Sendai, Miyagi 980-8577, Japan., Kerepesi C; Institute for Computer Science and Control (SZTAKI), Hungarian Research Network (HUN-REN), Budapest, Hungary., Kulkarni S; Department of Medicine, Center for Neurogastroenterology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Labunskyy VM; Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA., Levine ME; Altos Labs, Cambridge, United Kingdom., Libert S; Calico Life Sciences LLC, South San Francisco, CA 94080, USA., Lu JY; Altos Labs, Cambridge, United Kingdom., Lu YR; Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom., McCoy BM; School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA., Mitchell W; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Moqri M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Stanford University School of Medicine, Stanford, CA 94305, USA., Nasirian F; Northeastern University, Boston, MA 02115, USA., Niimi P; Altos Labs, Cambridge, United Kingdom., Oh HS; Stanford University School of Medicine, Stanford, CA 94305, USA., Okundaye B; Texas Tech University, Lubbock, TX 79409, USA., Parkhitko AA; Aging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA 15219, USA., Peshkin L; Department of Systems Biology, Harvard Medical School, Boston, MA 02115  USA., Petljak M; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA., Poganik JR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Pridham G; Dalhousie University, Halifax, NS B3H 4R2, Canada., Promislow DEL; Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MA 02111, USA., Prusisz W; Tecra Space., Quiniou M; Brain Research Institute, University of Zürich, Zürich, Switzerland., Raj K; Altos Labs Cambridge Institute of Science, Cambridge, CB21 6GP, United Kingdom., Richard D; Harvard University, Cambridge MA 02138, USA., Ricon JL; Retro Biosciences, Redwood City, CA, USA., Rutledge J; Stanford University School of Medicine, Stanford, CA 94305, USA., Scheibye-Knudsen M; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark., Schork NJ; The Translational Genomics Research Institute, Phoenix, AZ, USA., Seluanov A; Departments of Biology and Medicine, University of Rochester, Hutchison Hall, Rochester, NY 14627, USA., Shadpour M; Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA., Shindyapina AV; Retro Biosciences, Redwood City, CA, USA., Shuken SR; Harvard Medical School, Boston, MA 02115, USA., Sivakumar S; Retro Biosciences, Redwood City, CA, USA., Stoeger T; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; The Potocsnak Longevity Institute, Northwestern University, Chicago, IL 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Chicago, IL 60611, USA., Sugiura A; Juntendo University, Bunkyo City, Tokyo 113-8421, Japan., Sutton NR; Department of Internal Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Suvorov A; Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA., Tarkhov AE; Retro Biosciences, Redwood City, CA, USA., Teeling EC; School of Biology and Environmental Science, University College Dublin, Belfield Dublin 4, Ireland., Trapp A; Retro Biosciences, Redwood City, CA, USA., Tyshkovskiy A; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Unfried M; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ward-Caviness CK; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC 27514, USA., Yim SH; Texas Tech University, Lubbock, TX 79409, USA., Ying K; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Yunes J; Yunes Foundation for Research on Aging, Portsmouth, NH 03801, USA., Zhang B; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zhavoronkov A; Insilico Medicine, Cambridge, MA 02138, USA.
Jazyk:	angličtina
Zdroj:	PNAS nexus [PNAS Nexus] 2024 Dec 03; Vol. 3 (12), pp. pgae499. Date of Electronic Publication: 2024 Dec 03 (Print Publication: 2024).
DOI:	10.1093/pnasnexus/pgae499
Abstrakt:	To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion-even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as "aging" by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field. (© The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences.)
Databáze:	MEDLINE
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