Preparation and properties of a novel alginate/carrageenan crosslinked coordination polymer and evaluation of the antibacterial, antioxidant and anticancer potential of its Co(ii), and Cr(iii) polymeric complexes.

Autor: Al-Fakeh MS; Department of Chemistry, College of Science, Qassim University Buraidah 51452 Saudi Arabia., Al-Subaie NS; Department of Chemistry, College of Science, University of Bisha Bisha 61922 Saudi Arabia., El-Ghoul Y; Department of Chemistry, College of Science, Qassim University Buraidah 51452 Saudi Arabia., Hamden Z; Laboratory of Interfaces and Advanced Materials, Faculty of Sciences of Monastir, University of Monastir Monastir 5000 Tunisia.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2024 Dec 10; Vol. 14 (52), pp. 38934-38943. Date of Electronic Publication: 2024 Dec 10 (Print Publication: 2024).
DOI: 10.1039/d4ra06818a
Abstrakt: Natural polysaccharides play a crucial role across diverse fields such as medicine, food, and cosmetics, for their various physiochemical and biological properties. In this study, we developed a new crosslinked biopolymer using sodium alginate (AG) and carrageenan (CAR) polysaccharides. Various metal complexes involving different metal salts such as CoCl 2 ·6H 2 O and CrCl 3 ·6H 2 O were synthesized using the crosslinked biopolymer formed above. The two polymeric complexes were characterized using Fourier-transform infrared spectroscopy (FT-IR), elemental analysis, ultraviolet-visible spectroscopy (UV-Vis), magnetic susceptibility, molar conductivity techniques, and thermogravimetric analysis. The Co(ii) polymeric complex exhibits a tetrahedral X-ray crystal structure and belongs to the monoclinic crystal system. Cr(iii) complex is octahedral and crystal data are in compliance with the cubic crystal system. The antimicrobial study showed a significant activity improvement for all the developed complexes against both Gram-positive as well as Gram-negative bacterial pathogens - Staphylococcus aureus , Microscus luteum , Escherichia coli and Salmonella typhimurium. Similarly, the different polymeric complexes showed an efficient activity against Candida albicans as anti-fungal effect. Moreover, higher antioxidant values of the two complexes were obtained with DPPH scavenging activity ranging between 73% and 94%. In addition, both the polymeric complexes were subjected to biocompatibility cell viability assays along with in vitro anticancer evaluation. The alginate/carrageenan crosslinked coordination complexes revealed excellent cytocompatibility with normal human breast epithelial cells (MCF10A) and a high anticancer potential with human breast cancer cells (MCF-7) which increase significantly in a dose-dependent manner.
Competing Interests: The authors declare no conflicts of interest.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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