Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists.

Autor:	Fernandes HR; Department of Materials and Ceramic Engineering, CICECO-Aveiro Institute of Materials, University of Aveiro, Santiago University Campus, 3810-193, Aveiro, Portugal., Kannan S; Centre for Nanoscience and Technology, Pondicherry University, 605014, Puducherry, India., Alam M; Centre for Nanoscience and Technology, Pondicherry University, 605014, Puducherry, India., Stan GE; National Institute of Materials Physics, 077125, Magurele, Romania., Popa AC; National Institute of Materials Physics, 077125, Magurele, Romania., Buczyński R; Łukasiewicz Research Network - Institute of Microelectronics and Photonics, Al. Lotników 32/46, 02-668, Warsaw, Poland., Gołębiewski P; Łukasiewicz Research Network - Institute of Microelectronics and Photonics, Al. Lotników 32/46, 02-668, Warsaw, Poland., Ferreira JMF; Department of Materials and Ceramic Engineering, CICECO-Aveiro Institute of Materials, University of Aveiro, Santiago University Campus, 3810-193, Aveiro, Portugal.; Łukasiewicz Research Network - Institute of Microelectronics and Photonics, Al. Lotników 32/46, 02-668, Warsaw, Poland.
Jazyk:	angličtina
Zdroj:	Bioactive materials [Bioact Mater] 2024 Jun 08; Vol. 40, pp. 104-147. Date of Electronic Publication: 2024 Jun 08 (Print Publication: 2024).
DOI:	10.1016/j.bioactmat.2024.05.041
Abstrakt:	Over the past two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactive inorganic materials based on calcium phosphates and alkali-free bioactive glasses. A key focus has been the deliberate incorporation of therapeutic ions like Mg, Sr, Zn, Mn, or Ga to enhance osteointegration and vascularization, confer antioxidant properties, and impart antimicrobial effects, marking significant contributions to the field of biomaterials and bone tissue engineering. Such an approach is expected to circumvent the uncertainties posed by methods relying on growth factors, such as bone morphogenetic proteins, parathyroid hormone, and platelet-rich plasma, along with their associated high costs and potential adverse side effects. This comprehensive overview of CICECO-hub's significant contributions to the forefront inorganic biomaterials across all research aspects and dimensionalities (powders, granules, thin films, bulk materials, and porous structures), follows a unified approach rooted in a cohesive conceptual framework, including synthesis, characterization, and testing protocols. Tangible outcomes [injectable cements, durable implant coatings, and bone graft substitutes (scaffolds) featuring customized porous architectures for implant fixation, osteointegration, accelerated bone regeneration in critical-sized bone defects] were achieved. The manuscript showcases specific biofunctional examples of successful biomedical applications and effective translations to the market of bone grafts for advanced therapies. Competing Interests: The authors declare that they have no known competing/conflicting financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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