Noise causes cardiovascular disease: it's time to act.

Autor: Münzel T; Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. tmuenzel@uni-mainz.de.; German Center for Cardiovascular Research (DZHK), Partnersite Rhine-Main, Mainz, Germany. tmuenzel@uni-mainz.de.; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. tmuenzel@uni-mainz.de., Daiber A; Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partnersite Rhine-Main, Mainz, Germany.; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany., Engelmann N; Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Röösli M; Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Kuntic M; Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.; German Center for Cardiovascular Research (DZHK), Partnersite Rhine-Main, Mainz, Germany., Banks JL; Quiet Communities Inc., Concord, MA, USA.
Jazyk: angličtina
Zdroj: Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2024 Dec 10. Date of Electronic Publication: 2024 Dec 10.
DOI: 10.1038/s41370-024-00732-4
Abstrakt: Background: Chronic transportation noise is an environmental stressor affecting a substantial portion of the population. The World Health Organization (WHO) and various studies have established associations between transportation noise and cardiovascular disease (CVD), such as myocardial infarction, stroke, heart failure, and arrhythmia. The WHO Environmental Noise Guidelines and recent reviews confirm a heightened risk of cardiovascular incidents with increasing transportation noise levels.
Objective: We present a narrative review of the evidence from epidemiologic studies and translation studies on the adverse cardiovascular effects of transportation noise.
Methods: We describe the results of a recent Umbrella+ review that combines the evidence used in the 2018 WHO Environmental Noise Guidelines with more recent (post-2015) high-quality systematic reviews of original studies. High-quality systematic reviews were included based on the quality of literature search, risk of bias assessment, and meta-analysis methodology using AMSTAR 2.
Results: Epidemiologic studies show that exposure to high levels of road traffic noise for several years lead to numerous adverse health outcomes, including premature deaths, ischemic heart disease (IHD), chronic sleep disturbances, and increased annoyance. Mechanistically, noise exposure triggers oxidative stress, inflammation, endothelial dysfunction, and circadian rhythm disruptions. These processes involve the activation of NADPH oxidase, mitochondrial dysfunction, and nitric oxide synthase uncoupling, leading to vascular and cardiac damage. Studies indicate that chronic noise exposure does not result in habituation, and susceptible individuals, such as those with pre-existing CVD, are particularly vulnerable.
Competing Interests: Competing interests: The authors declare no competing interests. Ethical approval: Ethical approval was not required for this manuscript. Data used were obtained from the published literature. No data were directly obtained from human subjects.
(© 2024. The Author(s).)
Databáze: MEDLINE
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