Genomic perspective on the bacillus causing paratyphoid B fever.

Autor: Hawkey J; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, VIC, 3004, Australia., Frézal L; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Tran Dien A; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France.; Bioinformatic Core Facility, UMS AMMICA, Gustave Roussy, Villejuif, F-94800, France., Zhukova A; Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, F-75015, France., Brown D; Scottish Microbiology Reference Laboratories (SMiRL), Glasgow, G31 2ER, UK., Chattaway MA; Gastrointestinal Bacteria Reference Unit (GBRU), United Kingdom Health Security Agency, London, NW9 5EQ, UK., Simon S; Unit of Enteropathogenic Bacteria and Legionella (FG11)/National Reference Centre for Salmonella and Other Bacterial Enteric Pathogens, Robert Koch-Institute, Wernigerode, 38855, Germany., Izumiya H; Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan., Fields PI; Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA., De Lappe N; National Salmonella, Shigella and Listeria Reference Laboratory, Galway University Hospitals, Galway, SW4 671, Ireland., Kaftyreva L; Pasteur Institute of St Petersburg, St Petersburg, 197101, Russia., Xu X; Department of Microbiology, Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, 200336, China., Isobe J; Department of Bacteriology, Toyama Institute of Health, Toyama, 939-0363, Japan., Clermont D; Institut Pasteur, Université Paris Cité, Collection of Institut Pasteur (CIP), Paris, F-75015, France., Njamkepo E; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Akeda Y; Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan., Issenhuth-Jeanjean S; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Makarova M; Pasteur Institute of St Petersburg, St Petersburg, 197101, Russia., Wang Y; International Joint Research Centre for National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, 450046, China.; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, 100101, China., Hunt M; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, CB10 1SD, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; National Institute of Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Headley Way, Oxford, UK.; Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, University of Oxford, Oxford, UK., Jenkins BM; Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA., Ravel M; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Guibert V; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Serre E; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Matveeva Z; Pasteur Institute of St Petersburg, St Petersburg, 197101, Russia., Fabre L; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Cormican M; National Salmonella, Shigella and Listeria Reference Laboratory, Galway University Hospitals, Galway, SW4 671, Ireland.; School of Medicine, University of Galway, Galway, H91 TK33, Ireland., Yue M; Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, 310058, China.; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China., Zhu B; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, 100101, China., Morita M; Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan., Iqbal Z; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, CB10 1SD, UK.; Milner Centre for Evolution, University of Bath, Claverton Down, Bath, UK., Silva Nodari C; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Pardos de la Gandara M; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France., Weill FX; Institut Pasteur, Université Paris Cité, Unité des Bactéries pathogènes entériques, Paris, F-75015, France. francois-xavier.weill@pasteur.fr.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Dec 10; Vol. 15 (1), pp. 10143. Date of Electronic Publication: 2024 Dec 10.
DOI: 10.1038/s41467-024-54418-4
Abstrakt: Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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