Is ultrasound-guided radiofrequency ablation a reliable treatment option for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus: a retrospective comparative study based on large-sample data.
| Autor: | Zhou G; Hangzhou Weja Hospital, Hangzhou, China., Xu D; Department of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.; Wenling Institute of Big Data and Artificial Intelligence in Medicine, TaiZhou, China.; Taizhou Key Laboratory of Minimally Invasive Interventional Therapy & Artificial Intelligence, Taizhou, China., Zhang B; Hangzhou Weja Hospital, Hangzhou, China., Su R; Hangzhou Weja Hospital, Hangzhou, China., Xu K; Hangzhou Weja Hospital, Hangzhou, China., Zhang X; Hangzhou Weja Hospital, Hangzhou, China., Li F; Hangzhou Weja Hospital, Hangzhou, China., Zhao W; Hangzhou Weja Hospital, Hangzhou, China., Cai T; Hangzhou Weja Hospital, Hangzhou, China. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [Int J Hyperthermia] 2024; Vol. 41 (1), pp. 2438853. Date of Electronic Publication: 2024 Dec 10. |
| DOI: | 10.1080/02656736.2024.2438853 |
| Abstrakt: | Objective: To evaluate whether ultrasound-guided radiofrequency ablation (RFA) is reliable for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus (PTCI). Methods: 431 patients who underwent ultrasound-guided RFA for unifocal T1aN0M0 papillary thyroid carcinoma (PTC) were divided by location of the lesion into the PTCI group (52 females, 7 males, mean age 43.79 ± 12.04 years, range 22-74 years) and the PTCL group ((291 females, 81 males, mean age 43.42 ± 10.87 years, range 18-75 years) for comparative analysis. The efficacy of ultrasound-guided RFA was evaluated by volume reduction rate (VRR), complete disappearance rate (CDR) and disease progression, and the safety was evaluated by incidence of complications. Results: The two groups exhibited a consistent trend of change, with the PTCI group performing better in volume, VRR and CDR at all follow-up time points expect 1 month, but the differences were not statistically significant ( p > 0.05). The mean initial volume of the PTCI group vs the PTCL group decreased significantly from 65.4 ± 69.79 vs 86.38 ± 87.09 mm³ (range 10.92-427.58 vs 3.05-471.6 mm³) to 0 vs 0 mm³ at a mean follow-up time of 31.12 ± 12.5 months (range 12-60 months); their VRR increased significantly from -618.62 ± 655.61% vs -789.85 ± 1135.07% at 1 month to 100% vs 100% at 48 months. No disease progression was found in the two groups. The PTCI group had no complications, whereas the PTCL group had a total of 7 complications (1.88%). Conclusions: Ultrasound-guided RFA is reliable for unifocal T1aN0M0 PTCI. It can be promoted as an alternative to immediate surgery for selected PTC patients. |
| Databáze: | MEDLINE |
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