Illuminating anions in biology with genetically encoded fluorescent biosensors.

Autor: Cook MA; Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USA., Phelps SM; Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USA., Tutol JN; Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USA., Adams DA; Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USA., Dodani SC; Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USA. Electronic address: sheel.dodani@utdallas.edu.
Jazyk: angličtina
Zdroj: Current opinion in chemical biology [Curr Opin Chem Biol] 2024 Dec 09; Vol. 84, pp. 102548. Date of Electronic Publication: 2024 Dec 09.
DOI: 10.1016/j.cbpa.2024.102548
Abstrakt: Anions are critical to all life forms. Anions can be absorbed as nutrients or biosynthesized. Anions shape a spectrum of fundamental biological processes at the organismal, cellular, and subcellular scales. Genetically encoded fluorescent biosensors can capture anions in action across time and space dimensions with microscopy. The firsts of such technologies were reported more than 20 years for monoatomic chloride and polyatomic cAMP anions. However, the recent boom of anion biosensors illuminates the unknowns and opportunities that remain for toolmakers and end users to meet across the aisle to spur innovations in biosensor designs and applications for discovery anion biology. In this review, we will canvas progress made over the last three years for biologically relevant anions that are classified as halides, oxyanions, carboxylates, and nucleotides.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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