A narrative review about the intricate crosstalk among endometrium, adipose tissue, and neurons in endometriosis. The multifaceted role of leptin.

Autor: Neves D; Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal., Neto AC; Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal., Salazar M; Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal., Fernandes AS; Department of Obstetrics and Gynecology, Faculty of Medicine of the University of Porto, Porto, Portugal/Centro Hospitalar Universitário S. João, Porto, Portugal., Martinho M; Department of Obstetrics and Gynecology, Faculty of Medicine of the University of Porto, Porto, Portugal/Centro Hospitalar Universitário S. João, Porto, Portugal., Charrua A; Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; RISE-HEALTH@FMUP, Porto, Portugal., Rodrigues AR; Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal., Gouveia AM; Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal., Almeida H; Department of Biomedicine - Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal.
Jazyk: angličtina
Zdroj: Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2024 Dec 10, pp. e13879. Date of Electronic Publication: 2024 Dec 10.
DOI: 10.1111/obr.13879
Abstrakt: Endometriosis is a highly prevalent gynecological disease characterized by the presence of endometrium-like tissue outside the uterus, whose etiopathology is far from being elucidated. The most frequent complains of patients are pelvic pain and infertility. Increasing evidence supports the systemic impact of endometriosis suggesting that an intricate crosstalk among distinct organs underlies the development of the disease. In this setting, endometriosis patients present an increased risk for developing other diseases, such as cancer, cardiovascular pathologies, and autoimmune diseases, and manifest neurologic disturbances, including neuropathic hyperalgesia. Whilst the ovary-secreted estrogen dependency of ectopic endometrium growth is well established, we conjecture that adipose tissue-secreted molecules also intervene in endometriosis development and pain manifestation. In fact, women with endometriosis present a peculiar pattern of adipokine secretion that ensues the disease onset. Unexpectedly, the levels of adipose tissue-secreted molecules in those women present similarities with those found in patients with obesity, despite the recognized association of low body mass index with endometriosis. Taking this evidence into consideration, we hypothesize that endometriosis patients present a dysfunctional adipose tissue, which is associated with enhanced metabolism and unregulated browning that not only intervene in the control of body weight but also in peculiar pain processing pathways.
(© 2024 World Obesity Federation.)
Databáze: MEDLINE
Externí odkaz: