| Autor: |
Sutton B; Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
Science signaling [Sci Signal] 2024 Dec 10; Vol. 17 (866), pp. eadu0382. Date of Electronic Publication: 2024 Dec 10. |
| DOI: |
10.1126/scisignal.adu0382 |
| Abstrakt: |
Immunoglobulin E (IgE) binds with high affinity to its receptor, FcεRI, on mast cells and basophils, and cross-linking of allergen-specific IgE by minute amounts of multivalent allergen stimulates a powerful and immediate allergic reaction. In this issue of Science Signaling , Zhang et al. report the three-dimensional structures of the human and murine receptors, with and without bound IgE-Fc, to reveal some intriguing differences between mouse and human in this critical antibody-receptor interaction. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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