| Autor: |
Ma AD; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China., Chen WJ; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China., Sun WW; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China., Wu B; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.; Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, South-Central Minzu University, Wuhan 430074, China. |
| Abstrakt: |
We report here the synthesis of tricyclic nucleoside analogues via acid-catalyzed cyclization of guanine with 1,1,3,3-tetramethoxypropane. The method enables the use of hydroxyl-unprotected antiviral drugs (acyclovir, ganciclovir, and penciclovir), guanosines, oligonucleotide, and triazole-linked nucleoside dimers as substrates. Nucleoside trimer and tetramer were synthesized by derivatization reactions. |
